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个人简介
An international leader in the area of nutrition, obesity, metabolism and cancer, his lab focuses on the molecular and metabolic mechanisms underlying obesity-cancer associations, and the impact of obesity- energy balance modulation (eg, calorie restriction and exercise) or pharmacologic agents on cancer development, progression, and responses to chemotherapy. Primarily using genetically engineered mouse models of breast cancer (recently in parallel with several clinical trials), colon cancer and pancreatic cancer, Dr. Hursting has identified the IGF1/Akt/mTOR and NF-kB signaling pathways as key targets for breaking the obesity-cancer link. His publications establish causal links between obesity, cancer and several systemic factors (including IGF-1, insulin, leptin and IL-6) and components of their downstream signaling pathways (including mTOR and NF-kb).
研究兴趣
论文共 504 篇作者统计合作学者相似作者
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Elaine M Glenny, Alyssa N Ho,Violet A Kiesel, Fangxin Chen,Claire E Gates,Evan M Paules, Ruihan Xu, C Alex Holt,Michael F Coleman,Stephen D Hursting
bioRxiv : the preprint server for biology (2024)
CANCER RESEARCHno. 3 (2024)
Cancer Researchno. 6_Supplement (2024): 1784-1784
Carol Fabian, Adrian Zelenchuk,Kandy Powers,Amy Kreutzjans, Krystal Pittman, Bill Hendry, Christy Altman,Erin Giles,Katherine L. Cook,Stephen Hursting,Bruce Kimler
Cancer Researchno. 9_Supplement (2024): PO2-08
Victoria M. Bandera,Tengda Lin,Caroline Himbert,Elaine M. Glenny,Aik Choon Tan,Jennifer Ose,Christy Warby, Olena Aksonova, Alessandro Carpanese, Chris Stubben,David Nix,Kenneth Boucher,
Cancer Researchno. 6_Supplement (2024): 3406-3406
Cancer Researchno. 9_Supplement (2024): PS07-08
Ziyi Zhao,Jiandong Wang,Weimin Kong,Ziwei Fang,Michael F. Coleman, Ginger L. Milne,Wesley C. Burkett,Meredith A. Newton, Olivia Lara,Douglas Lee, Boer Deng,Xiaochang Shen,
Cancer Researchno. 9_Supplement (2024): PO5-14
crossref(2023)
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