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职业迁徙
个人简介
We am aim to understand how signalling within and between cells is used to regulate the physiology and development of animals. In particular we are studying how signalling networks that use the second messengers calcium and inositol 1,4,5-trisphosphate (IP3) are used to control the biology of C. elegans. Our research is always driven by a desire to integrate a mechanistic understanding of cell and molecular processes with whole animal function as revealed and measured by development, physiological function or behaviour. In one current project we are defining the mechanism by which cell signalling pathways regulate RNAi. In another we are dissecting interactions between calcium signalling and presenilins. Presenilins are of particular interest because mutations in human presenilins cause familial Alzheimer’s disease.
In addition to this work I have an ongoing interest in collaborating with other laboratories to generate C. elegans models of human disease.
To tackle these questions we use a combination of approaches including; RNAi and genetics to perturb and analyse gene function, protein interaction techniques, cell biological and microscopical approaches to address function and assays of whole animal function.
In addition to this work I have an ongoing interest in collaborating with other laboratories to generate C. elegans models of human disease.
To tackle these questions we use a combination of approaches including; RNAi and genetics to perturb and analyse gene function, protein interaction techniques, cell biological and microscopical approaches to address function and assays of whole animal function.
研究兴趣
论文共 84 篇作者统计合作学者相似作者
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James S Santangelo,Rob W Ness,Beata Cohan,Connor R Fitzpatrick, Simon G Innes, Sophie Koch,Lindsay S Miles, Samreen Munim,Pedro R Peres-Neto,Cindy Prashad, Alex T Tong,Windsor E Aguirre,
semanticscholar(2017)
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Developmentno. 12 (2015)
Anikó I. Nagy,Rafael P. Vázquez-Manrique, Marie Lopez,Christo P. Christov, María Dolores Sequedo, Mareike Herzog, Anna E Herlihy, Maxime Bodak,Roxani Gatsi,Howard A. Baylis
semanticscholar(2014)
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