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个人简介
Our translational animal experimental research focuses on (serotonergic) genetic and environmental factors that influence brain development and behavioural traits. Interactions between these factors may lead to maladaptive emotional responses as seen in stress-related disorders and addiction, but also cognitive improvements, depending on environmental conditions. It is our overarching hypothesis that the cognitive improvements can be used to offset the maladaptive emotional responses. To test this hypothesis we use unique mutant rats that model human genetic polymorphisms, including the serotonin transporter knockout rat. We also investigate the role of serotonin and environmental factors in brain development and long-term effects on behaviour and cognition. Our main expertise is measuring basic and complex (translational) behaviours in rats, which we combine with invasive measurements, pharmacological manipulations, in vivo neurochemical measurements and neuroimaging, molecular genetic analyses, and immunohistochemical assessments.
研究兴趣
论文共 274 篇作者统计合作学者相似作者
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Yami Bright,Dorien A. Maas,Michel M. M. Verheij,Maria S. Paladini, Helene I. V. Amatdjais-Groenen,Raffaella Molteni,Marco A. Riva,Gerard J. M. Martens,Judith R. Homberg
CURRENT NEUROPHARMACOLOGYno. 2 (2024): 323-338
Xianzong Meng, Ping Chen,Andor Veltien, Tony Palavra, Sjors In't Veld,Joanes Grandjean,Judith R. Homberg
NEUROBIOLOGY OF STRESS (2024): 100585-100585
Ghazaleh Ghamkhari Nejad,Francesca Mottarlini,Zohreh Tavassoli,Lucia Caffino,Fabio Fumagalli,Judith R. Homberg,Yaghoub Fathollahi
ADDICTION BIOLOGYno. 3 (2024): e13377-e13377
Psychopharmacologyno. 3 (2024): 613-625
Menghan Sun,Paola Brivio,Ling Shan, Sylvia Docq, Lisa C. M. W. Heltzel, Celine A. J. Smits,Anthonieke Middelman, Roel Vrooman,Marcia Spoelder,Michel M. M. Verheij,Jan K. Buitelaar, Morgane Boillot,
Mina Sadighi, Lingling Mai, Yifan Xu, Morgane Boillot,Giorgia Targa,Francesca Mottarlini,Paolo Brambilla,Peter Gass,Lucia Caffino,Fabio Fumagalli,Judith R. Homberg
JOURNAL OF AFFECTIVE DISORDERS (2024): 128-142
Neuroscience and biobehavioral reviews (2024): 105605-105605
Bart C. J. Dirven, Lennart van Melis, Teya Daneva, Lieke Dillen,Judith R. Homberg,Tamas Kozicz,Marloes J. A. G. Henckens
NEUROSCIENCE (2024): 87-102
Life (Basel, Switzerland)no. 4 (2023)
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