My research is focused on first-principles calculations of atomic nuclei across all mass regions. I am particularly interested in linking ongoing developments of two and three-nucleon forces rooted in QCD with nuclear structure issues at and beyond the experimental frontiers, such as determining the limits of existence of matter and the evolution of magic numbers towards these limits. Furthermore this work has deep connections to some of the most compelling unanswered questions in beyond-standard-model physics. For instance neutrinoless double beta decay can provide a direct path to knowledge of neutrino masses, WIMP-nucleus scattering may lead to understanding the nature of dark matter, and particular nuclear transitions provide insights into physics at the electroweak scale and beyond. Since these methods are quite general, they can also be broadly extended to other many-body problems such as atomic systems.