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We identified vascular progenitor cells (VPC) derived from ES cells and showed the clinical implication for ES cells-derived VPC (Nature 2000, Blood 2003, Circulation 2003). We have also demonstrated that natriuretic peptides (NPs) activate cGMP/cGK pathway for cardiovascular homeostasis (JCI 1988, JCI 1992, Lancet 1992) and further reported that NPs promote vascular regeneration in atherosclerotic lesions (Circulation 2002, PNAS 2003, Endocrinology 2008). We recently demonstrated the novel action of cardiovascular hormones on mitochondrial function. We reported that angiotensin inhibits mitochondria biogenesis and induces insulin resistance (Diabetes 2008)and that the transgenic mice for activating NP system suppress diet-induced obesity and expand life spans by inducing a silent information regulator (Sirt1) which enhances mitochondrial function (Diabetes 2009). We are now examining the role of Sirt1 in the kidney, especially in the renal tubules, which consume large energy, by using in-vitro systems (BBRC 2008) and by generating kidney-specific transgenic and knock-out mice.
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Eriko Yoshida Hama,Ran Nakamichi,Akihito Hishikawa, Miho Kihara,Takaya Abe,Norifumi Yoshimoto, Erina Sugita Nishimura,Hiroshi Itoh,Kaori Hayashi
Biochemical and biophysical research communications (2024): 149713-149713
Shintaro Yamaguchi,Junichiro Irie,Masanori Mitsuishi,Yuichi Uchino, Hideaki Nakaya,Ryo Takemura,Emi Inagaki, Shotaro Kosugi,Hideyuki Okano,Masato Yasui,Kazuo Tsubota,Kaori Hayashi,
ENDOCRINE JOURNALno. 2 (2024): 153-169
Diabetology Internationalpp.1-9, (2024)
Journal of Hypertensionno. Suppl 1 (2023): e386-e386
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JOURNAL OF HYPERTENSION (2023): E402-E402
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JOURNAL OF HYPERTENSION (2023): E350-E350
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THERAPEUTIC APHERESIS AND DIALYSIS (2023)
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JOURNAL OF HYPERTENSION (2023): E351-E351
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JOURNAL OF HYPERTENSION (2023): E321-E321
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