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个人简介
Research efforts in the Lashuels laboratory focus on understanding the molecular mechanisms of neurodegeneration and developing novel strategies to diagnose and treat neurodegenerative diseases such as Alzheimers and Parkinsons disease. Research in the Lashuel lab is funded by several international funding agencies and foundations, including the Swiss National Science Foundation, European FP7 program (Marie Curie and ERC grants), Human Science Frontiers, Strauss Foundation, Cure the Huntingtons disease foundation and Michael J Fox foundation and is supported by collaborations with pharmaceutical and biotech companies (http://lashuel-lab.epfl.ch/page-50538-en.html), Nestle, Merck-Serono, AC Immune and Johnson and Johnson. Dr. Lashuels research has resulted in the characterization of novel quaternary structure intermediates on the amyloid pathway, identification of potential therapeutic targets, and new hypotheses concerning the mechanisms of pathogenesis in Alzheimers disease, Parkinsons disease and related disorders. Dr. Lashuel scientific contribution to this field includes i) more than100 publications in major peer reviewed journals including Nature journals, Cell, PNAS, JBC, J. Neuroscience JACS, and Angewandtie Chemie; ii) three patents on novel strategies for preventing protein aggregation and treating autoimmune and inflammatory diseases; iii) more than 150 invited lectures since 2002 and more than 5500 citations (7800 citation-Google Scholar) since 1996. Dr. Lashuel has received several pre-doctoral and post-doctoral awards and fellowships and was the recipient of two prestigious awards given to young investigators; Human Science Frontiers young investigator research award and the European Research Council (ERC) starting independent researcher grant and the ERC proof of concept award (2013) These awards provide more than $2.5 Million to Dr. Lashuel to translate some of his ideas and projects into novel strategies for diagnosing and treating neurodegenerative diseases such as Alzheimers and Parkinsons disease. Dr. Lashuel has chaired and co-organized several international conferences and serves as an academic editor for PLoS ONE, an associate editor for frontiers of molecular neuroscience, member of the Editorial advisory board of ChemBioChem and ad hoc reviewer for several international scientific journals and funding agencies.
研究兴趣
论文共 270 篇作者统计合作学者相似作者
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Aaron T. Balana,Anne-Laure Mahul-Mellier,Binh A. Nguyen,Mian Horvath,Afraah Javed,Eldon R. Hard,Yllza Jasiqi, Preeti Singh,Shumaila Afrin, Rose Pedretti,Virender Singh,Virginia M.-Y. Lee,
Aaron T. Balana,Anne-Laure Mahul-Mellier,Binh A. Nguyen,Mian Horvath,Afraah Javed,Eldon R. Hard,Yllza Jasiqi, Preeti Singh,Shumaila Afrin, Rose Pedretti,Virender Singh,Virginia M. -Y. Lee,
NATURE CHEMICAL BIOLOGY (2024)
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI (2024)
ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONno. 3 (2024): e202314587-e202314587
npj Parkinson's Diseaseno. 1 (2024): 1-1
Aaron T. Balana,Anne-Laure Mahul-Mellier,Binh A. Nguyen,Mian Horvath,Afraah Javed,Eldon R. Hard,Yllza Jasiqi, Preeti Singh,Shumaila Afrin, Rose Pedretti,Virender Singh,Virginia M. -Y. Lee,
ACS chemical neuroscienceno. 1 (2023): 193-204
Yogesh Singh,Christoph Trautwein, Joan Romani,Madhuri S. Salker,Peter H. Neckel,Isabel Fraccaroli,Mahkameh Abeditashi,Nils Woerner,Jakob Admard,Achal Dhariwal, Morten K. D. Dueholm,Karl-Herbert Schäfer,
biorxiv(2023)
Shujing Zhang,Ruowei Zhu,Buyan Pan,Hong Xu,Modupe F. Olufemi,Ronald J. Gathagan,Yuanxi Li,Luyan Zhang,Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan,Xingjun Cao,
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