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Neural stem cells (NSCs) possess the capability for self-renewal and are multipotent, that is, they can give rise to both neurons and glial cells. Embryonic NSCs are expected as a source for transplantation therapy, and adult NSCs as a basis of noninvasive treatment of neurological disorders. However, because the fate of embryonic NSCs is generally predetermined and restricted temporally, a given embryonic NSC cannot generate all of the cell types existing in the CNS. For example, early NSCs generate neurons but not glia; later NSCs generate both types of cells, however, they cannot give rise to early-born neurons. Meanwhile, actual use of adult NSCs for regenerative medicine is a vision far from being fulfilled because of the as-yet unexplored physiology and mechanisms of adult neurogenesis.To resolve these problems, we propose to establish in-vitro culture systems, and to develop a powerful model for investigating the mechanisms underlying early CNS development. Furthermore, we are examining adult neurogenesis both anatomically and physiologically by combining comprehensive in-vitro analyses, such as DNA microarray and ChIP-sequencing, and in-vivo analyses using knockout or knock-in mice. Findings from these approaches are expected to be applicable to regenerative therapy for neurodegenerative disorders.
Research Areas【 Display / hide 】
Life Science / Molecular biology (Molecular Biology)
Life Science / Developmental biology (Developmental Biology)
Life Science / Neuroscience-general (General Neuroscience)
Research Areas【 Display / hide 】
Life Science / Molecular biology (Molecular Biology)
Life Science / Developmental biology (Developmental Biology)
Life Science / Neuroscience-general (General Neuroscience)
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论文共 1806 篇作者统计合作学者相似作者
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Spine surgery and related researchno. 1 (2024): 22-28
Syoichi Tashiro, Shinsuke Shibata,Narihito Nagoshi, Liang Zhang,Shin Yamada,Tetsuya Tsuji,Masaya Nakamura,Hideyuki Okano
Cellsno. 5 (2024): 412
Neural regeneration researchno. 4 (2024): 818-824
Naoya Hayashi,Junichi Hata, Tetsu Yoshida,Daisuke Yoshimaru,Yawara Haga,Hinako Oshiro, Ayano Oku,Noriyuki Kishi,Takako Shirakawa,Hideyuki Okano
PloS oneno. 2 (2024): e0297273-e0297273
crossref(2024)
Kinya Matsuo, Kazuhiro Nagata, Ryusei Umeda, Takaya Shiota,Satoru Morimoto,Naoki Suzuki,Masashi Aoki,Hideyuki Okano, Masayuki Nakamori,Hideaki Nishihara
biorxiv(2024)
Experimental Neurology (2024): 114700-114700
Sopak Supakul,Rei Murakami, Chisato Oyama,Tomoko Shindo,Yuki Hatakeyama, Maika Itsuno,Hiroko Bannai,Shinsuke Shibata,Sumihiro Maeda,Hideyuki Okano
Inflammation and Regenerationno. 1 (2024): 1-21
Inflammation and Regenerationno. 1 (2024): 1-11
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