基本信息
浏览量:66
职业迁徙
个人简介
Hidde Ploegh’s laboratory is interested in the biochemistry of immune recognition, and in mechanisms by which pathogens avoid being seen by the immune system. His earlier work centered on the analysis of the biochemical pathways involved in antigen processing and presentation by the products of the Major Histocompatibility Complex (MHC), which led to studies into glycoprotein biosynthesis and trafficking more generally. The discovery that human cytomegalovirus exploits an unusual mechanism to dispose of Class I MHC products, critical for recognition by cytotoxic T cells of virus-infected cells, led to observations that illuminated new aspects of glycoprotein quality control. Ploegh has applied chemistry to develop activity-based probes to study proteasomal proteolysis and more specifically the role of ubiquitin-specific proteases, also in the context of herpesvirus infections. More recently Ploegh has combined the generation of camelid-derived antibody fragments with a protein engineering approach, based on the use of bacterial sortases in conjunction with peptide chemistry. This combination is being developed to enable the visualization, by non-invasive means, of anti-tumor and anti-virus immune responses using positron emission tomography.
研究兴趣
论文共 55 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Proceedings of the National Academy of Sciences of the United States of Americano. 50 (2023)
引用0浏览0WOS引用
0
0
Novalia Pishesha,Thibault J Harmand,Paul W Rothlauf,Patrique Praest, Ryan K Alexander,Renate van den Doel,Mariel J Liebeskind,Maria A Vakaki,Nicholas McCaul,Charlotte Wijne, Elisha Verhaar,William Pinney,
Tao Fang, Catharina H. M. J. Van Elssen,Joao Daniel Nunes Duarte, Jonathan S. Guzman,Jasdave S. Chahal,Jingjing Ling,Hidde L. Ploegh
semanticscholar(2017)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn