基本信息
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职业迁徙
个人简介
Dr. Morse graduated from Harvard Medical School and then completed his internship and residency at Peter Bent Brigham Hospital, Boston. Following postdoctoral studies at NIAID, he joined the Laboratory of Viral Diseases in 1980 and became chief of the Laboratory of Immunopathology (LIP) in 1985. In 2011, LIP merged with the Laboratory of Immunogenetics, and Dr. Morse became chief of the Virology and Cellular Immunology Section.
Research Topics:
Studies in the Virology and Cellular Immunology Section are focused on understanding mechanisms involved in normal B-cell differentiation and function and in the development of B-cell lymphomas. Other work centers on understanding host and viral determinants of murine leukemia virus (MuLV) expression and their effects on the immune system. Basic biologic problems are probed through the use of congenic, transgenic, and knockout mice; analyses of lymphoma cell lines; DNA and tissue microarrays; and molecular and cell biology.
Work from the Virology and Cellular Immunology Section provided the foundation for developing new consensus nomenclatures for mouse hematopoietic neoplasms based primarily on histopathologic criteria. This classification system is being strengthened and revised through the use of gene expression profiling, immunohistochemical analyses of tissue arrays and examination of genes affected by MuLV proviral insertional mutagenesis.
A variety of bioinformatic approaches to examining data from DNA microarrays are used to identify genes involved in processes of B-cell differentiation and transformation. All this work is facilitated by the availability of a large, unparalleled repository of tissue samples, DNA, and material for frozen sections from primary lymphomas; and a large number of derivative cell lines. Important directions can be extended to human B cells and lymphomas through productive collaborations.
Selected Publications:
Hao X, Fredrickson TN, Chattopadhyay SK, Han W, Qi CF, Wang Z, Ward JM, Hartley JW, Morse HC 3rd. The histopathologic and molecular basis for the diagnosis of histiocytic sarcoma and histiocyte-associated lymphoma of mice. Vet Pathol. 2010;47(3):434-45.
Qi CF, Shin DM, Li Z, Wang H, Feng J, Hartley JW, Fredrickson TN, Kovalchuk AL, Morse HC 3rd. Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice. J Pathol. 2010;221(1):106-16.
Li Z, Wang H, Xue L, Shin DM, Roopenian D, Xu W, Qi CF, Sangster MY, Orihuela CJ, Tuomanen E, Rehg JE, Cui X, Zhang Q, Morse HC 3rd, Morris SW. Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma. Blood. 2009;114(19):4158-68.
Zhou JX, Lee CH, Qi CF, Wang H, Naghashfar Z, Abbasi S, Morse HC 3rd. IFN regulatory factor 8 regulates MDM2 in germinal center B cells. J Immunol. 2009;183(5):3188-94.
Shin DM, Shaffer DJ, Wang H, Roopenian DC, Morse HC 3rd. NOTCH is part of the transcriptional network regulating cell growth and survival in mouse plasmacytomas. Cancer Res. 2008;68(22):9202-11.
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