基本信息
浏览量:62
职业迁徙
个人简介
The Sucov lab uses advanced genetic strategies to identify pathways and processes that influence cardiomyocyte proliferation and heart regeneration. A common adult heart injury is a myocardial infarction (heart attack), which results in loss of myocardium. In typical circumstances, this lost tissue is not regenerated, which leads to compromised function and can progress to heart failure (the leading cause of death in the US and globally). In contrast, fetal and neonatal hearts can fully regenerate after injury. The Sucov lab addresses fundamental basic questions about heart biology: what causes cardiomyocytes after birth to become postmitotic, why does this occur, would there be detrimental consequences if adult hearts were more highly regenerative? They have developed completely new paradigms and unique experimental strategies to explain these aspects of heart biology. In addition, they apply their insights to address the obvious clinical need to develop better therapeutic options in the aftermath of a heart attack. The lab primarily studies heart biology in mice, although also makes use of cell-based approaches and other experimental animal models, and the work has surprisingly extensive application to human genetics and human heart pathophysiology.
研究兴趣
论文共 116 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
biorxiv(2024)
biorxiv(2023)
引用0浏览0引用
0
0
Journal of cardiovascular development and diseaseno. 4 (2023): 161-161
Bethany N. Radford, Xiang Zhao, Tali Glazer, Malcolm Eaton,Danielle Blackwell,Shuhiba Mohammad,Lucas Daniel Lo Vercio,Jay Devine,Tali Shalom-Barak,Benedikt Hallgrimsson,James C. Cross,Henry M. Sucov,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn