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个人简介
Helen Saibil is a molecular biologist who uses three-dimensional electron microscopy to examine the cellular machines that carry out the functions of life. Her work has resulted in the remarkable visualisation of both molecular chaperones — proteins that help other macromolecules fold and unfold — and the misfolding of proteins that form fibrils implicated in amyloid disease.
Her most recent studies have investigated the operation of perforin, a protein ‘weapon’ used by the immune system to punch holes in cancerous or infected cells, through which destructive enzymes can subsequently travel. These findings stem from Helen’s previous research on a similar pore-forming bacterial toxin.
In addition to being a Fellow of the Society, Helen is a Fellow of the Academy of Medical Sciences, an Honorary Member of the British Biophysical Society and an Honorary Fellow of the Royal Microscopical Society. She has also received a number of awards for her work, including a five-year programme grant from the Wellcome Trust in 2009.
研究兴趣
论文共 195 篇作者统计合作学者相似作者
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crossref(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Proceedings of the National Academy of Sciences of the United States of Americano. 50 (2023): e2308933120-e2308933120
Guendalina Marini,Brad Poland,Chris Leininger,Natalya Lukoyanova, Dan Spielbauer,Jennifer K. Barry,Dan Altier,Amy Lum, Eric Scolaro,Claudia Pérez Ortega,Nasser Yalpani, Gary Sandahl,
Nature Communicationsno. 1 (2023): 1-11
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Guendalina Marini,Brad Poland,Chris Leininger,Natalya Lukoyanova, Dan Spielbauer,Jennifer Barry,Dan Altier,Amy Lum, Eric Scolaro,Claudia Perez Ortega, Nassan Yalpani, Gary Sandahl,
biorxiv(2022)
Joseph George Beton, Jim Monistrol,Anne Wentink, Erin C Johnston,Anthony John Roberts,Bernd Gerhard Bukau,Bart W Hoogenboom,Helen R Saibil
Saskia E Bakker,David Bhella, Rosaria Brescia,Per Bullough,Daniel K Clare,Bertram Daum,René A W Frank,Vicki A M Gold, Isobel Jackson Hirst,Werner Kühlbrandt,Penghan Lu,Mathew McLaren,
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