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个人简介
Our research programme uses large scale population based approaches to further our understanding of the pathogenesis and means of prevention of diabetes complications. A main component of our current work harnesses the increasing availability of e-health record data (EHR) and new technologies for acquiring high dimensional molecular ‘omics data. We quantify contemporaneous absolute risks of complications, evaluate risk factors for complications, and build prediction models using e-health record data. These data are used to inform current health care policy and clinical practice in diabetes. We also use large bioresources linked to these data to quantify the marginal improvement gained by genetics and biomarker panels beyond that achieved by EHR data. Our aim is that these prediction algorithms will then be incorporated into prediction tools for clinical and self-management, and will be useful in clinical trial design. These genetics and biomarker studies also yield important information on the pathogenesis of diabetes complications, that, with more detailed wet-lab research with colleagues in the Institute of Genetics and Cancer, can inform future development of new therapies. Our research programme also encompasses the design and conduct of clinical trials of new drugs and approaches for preventing diabetes complications.
研究兴趣
论文共 425 篇作者统计合作学者相似作者
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The British journal of general practice : the journal of the Royal College of General Practitioners (2024)
Esther Latres,Carla J Greenbaum, Maria L Oyaski,Colin M Dayan,Helen M Colhoun,John M Lachin,Jay S Skyler,Michael R Rickels,Simi T Ahmed, Sanjoy Dutta,Kevan C Herold, Marjana Marinac
Diabetes (2024)
Joe Mellor, Anita Jeyam,Joline WJ. Beulens,Sanjeeb Bhandari, Geoffrey Broadhead,Emily Chew,Ward Fickweiler,Amber van der Heijden,Daniel Gordin,Rafael Simó,Janet Snell-Bergeon,Anniina Tynjälä,
Ophthalmology Sciencepp.100494, (2024)
Journal of applied physiology (Bethesda, Md. : 1985)no. 1 (2024): 13-22
The British journal of ophthalmology (2024)
American journal of human geneticsno. 6 (2023): 913-926
British Journal of Ophthalmologypp.bjo-323395, (2023)
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A. Michael Lincoff, Kirstine Brown-Frandsen,Helen M. Colhoun,John Deanfield,Scott S. Emerson,Sille Esbjerg, Soren Hardt-Lindberg,G. Kees Hovingh,Steven E. Kahn,Robert F. Kushner,Ildiko Lingvay, Tugce K. Oral,
NEW ENGLAND JOURNAL OF MEDICINE (2023)
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