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个人简介
My research focuses on the molecular pathogenesis of gastrointestinal tract cancers. My team and I are currently establishing a “living biobank” with cancer and paired normal gastrointestinal organoids derived from freshly resected patient’s specimens. We use this ever-growing 3D organoid culture as a disease model together with gene transfection and genome-editing techniques to study the functional roles of newly identified tumor driver genes such as RHOA in gastric cancer. Patient-derived cancer organoid culture which represents the entire repertoire of diverse molecular subtypes of gastrointestinal cancer is one of the best platforms for drug sensitivity screening and identification of new candidate drugs for personalized cancer therapy.
研究兴趣
论文共 39 篇作者统计合作学者相似作者
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Sarah SK Yue,Yin Tong,Hoi Cheong Siu,Siu Lun Ho,Simon YK Law,Wai Yin Tsui,Dessy Chan,Yuanhua Huang,Annie SY Chan, Shui Wa Yun,Ho Sang Hui,April S Chan,
biorxiv(2024)
CANCER SCIENCE (2023): 245-245
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Cell stem cellno. 7 (2023): 917-937
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Basic Gastroenterology (2022)
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