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Research activity in our group is focused on developing sustainable synthetic methods using biocatalysts in single-step reactions, multi-step cascades and performing reactions in water. Current projects include biocatalyst discovery using functional metagenomics approaches and the use of biocatalytic synthetic strategies with transaminases, tranketolases, ene reductases, decarboxylases, tyrosinases, imine reductases, alcohol dehydrogenases, methyl transferases and norcoclaurine synthases. The combination of enzyme steps into biocatalytic cascades and synthetic biology pathways is a particularly efficient method for molecular assembly which we are exploring. A recent focus has also been the use of biomass waste, as a sustainable starting material to produce higher value compounds. As well as the use of enzymes for synthetic applications, we are investigating the discovery and use of enzymes for the degradation of plastics and other waste materials for molecular recycling. In addition organic reactions in water have been a research activity for several year
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论文共 252 篇作者统计合作学者相似作者
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RSC Advancesno. 6 (2024): 4264-4273
CATALYSIS SCIENCE & TECHNOLOGY (2024)
Frontiers in Sustainability (2023)
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Douglas Weber, Lucas de Souza Bastos,Margit Winkler, Yeke Ni,Abil E. Aliev,Helen C. Hailes,Doerte Rother
RSC ADVANCESno. 15 (2023): 10097-10109
Fabiola Sciscione,Simon Guillaume,Abil E. Aliev, Declan T. Cook,Hugo Bronstein,Helen C. Hailes,Paul C. Beard,Tammy L. Kalber,Olumide Ogunlade,Alethea B. Tabor
BIOORGANIC & MEDICINAL CHEMISTRY (2023): 117412-117412
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