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In the early 1980s his research group was the first to clone a mammalian glucose transport protein, GLUT1, and then the insulin- responsive GLUT4 glucose transporter. They also cloned and characterized the first transporter proteins for anions and free fatty acids. In 1988, the Lodish laboratory pioneered a new cloning technology to isolate the gene encoding the receptor for erythropoietin (Epo), the hormone that controls the production of red blood cells. This led to a lengthy set of projects on the activation of, and signal transduction by, the erythropoietin receptor in erythroid progenitor cells and the regulation of transcription, apoptosis, and cell division. Later the lab characterized many novel genes that are important for terminal stages of erythropoiesis, including chromatin condensation and enucleation. Other projects focused on the regulation of self- renewal, proliferation, and differentiation of early (BFU-E) erythroid progenitor cells by extracellular signals including glucocorticoids and oxygen, with the goal of developing novel therapies for erythropoietin-resistant anemias.
The lab discovered several microRNAs and Long Non-coding RNAs that are specifically expressed in developing red blood cells and that regulate important aspects of development including cell death. One microRNA, miR-125b, causes leukemias when overexpressed in human or mouse stem cells. Another recent discovery revealed why patients with an underactive thyroid tend to have anemia: A lack of the thyroid hormone thyroxin inhibits maturation of red blood cell progenitors.
The lab discovered several microRNAs and Long Non-coding RNAs that are specifically expressed in developing red blood cells and that regulate important aspects of development including cell death. One microRNA, miR-125b, causes leukemias when overexpressed in human or mouse stem cells. Another recent discovery revealed why patients with an underactive thyroid tend to have anemia: A lack of the thyroid hormone thyroxin inhibits maturation of red blood cell progenitors.
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Mai-Jing Liao,Cheng Cheng Zhang,Beiyan Zhou,Drazen B. Zimonjic,Sendurai A. Mani, Megan Kaba, Ann Gifford,Ferenc Reinhardt, Nicholas C. Popescu,Wenjun Guo,Elinor Ng Eaton,Harvey F. Lodish,
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