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Brain function is based upon the precise connectivity of a large number of neurons. Connectivity in turn depends in large part on the genetically determined wiring properties of neurons, including their neurite projection, branching, and placement of synaptic contacts with specific partners. Research of my lab revolves around the question how gene expression controls neuronal connectivity and, thereby, brain function. We use the model system Drosophila, where virtually every gene can be targeted for knock-out or activation in a cell type selective manner Drosophila also offers the advantage that its brain is composed of a relatively small number of stereotyped neuronal lineages, groups of neurons descended from individual embryonic stem cells, called neuroblasts.
A longstanding line of research in our lab is to reconstruct how lineages assemble the major circuits of the fly brain. For the small larval brain, this reconstruction can now be done at a so far unparalleled level of resolution, using a series of several thousand contiguous electron microscopic sections in conjunction with a specially developed software package that allows us to assign all synapses to specific neurons and their lineages.
Brain function is based upon the precise connectivity of a large number of neurons. Connectivity in turn depends in large part on the genetically determined wiring properties of neurons, including their neurite projection, branching, and placement of synaptic contacts with specific partners. Research of my lab revolves around the question how gene expression controls neuronal connectivity and, thereby, brain function. We use the model system Drosophila, where virtually every gene can be targeted for knock-out or activation in a cell type selective manner Drosophila also offers the advantage that its brain is composed of a relatively small number of stereotyped neuronal lineages, groups of neurons descended from individual embryonic stem cells, called neuroblasts.
A longstanding line of research in our lab is to reconstruct how lineages assemble the major circuits of the fly brain. For the small larval brain, this reconstruction can now be done at a so far unparalleled level of resolution, using a series of several thousand contiguous electron microscopic sections in conjunction with a specially developed software package that allows us to assign all synapses to specific neurons and their lineages.
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Cell Reportsno. 3 (2024): 113791-113791
Philipp Schlegel,Yijie Yin,Alexander Shakeel Bates,Sven Dorkenwald,Katharina Eichler,Paul Brooks,Daniel Han, Marina Gkantia, Maria João Heitor dos Santos, Eva J Munnelly, Griffin Badalamente, Laia Serratosa Capdevila,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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JOURNAL OF NEUROSCIENCEno. 44 (2023): 7393-7428
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiologyno. 4 (2023): 679-720
Philipp Schlegel,Yijie Yin, Alexander S Bates,Sven Dorkenwald,Katharina Eichler,Paul Brooks,Daniel S Han,Marina Gkantia, Marcia Dos Santos, Eva J Munnelly,Griffin Badalamente, Laia Serratosa Capdevila,
bioRxiv : the preprint server for biology (2023)
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