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Harold Weintraub contributed greatly to our understanding of how gene expression leads to differentiation of cell types. He studied the globin gene during erythroid maturation, and the results determined the structure of the chromosome and how it changed during transcription and replication. He also demonstrated that the altered structures around the globin genes were potentially a consequence of DNA supercoiling, a process required for successful transcription. Weintraub’s research culminated with two groundbreaking discoveries: first, he discovered MyoD, a DNA-binding protein that was capable of converting a variety of other cells into myoblasts; this changed how scientists viewed gene expression during embryonic development forever. Second, he devised a procedure that used anti-sense RNA to deactivate the expression of specific genes, which allowed for the genetic analysis of cells in more complex organisms such as vertebrates.
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Proceedings of the National Academy of Sciences of the United States of Americano. 17 (1993): 8028-8032
Cold Spring Harbor Monograph Archivepp.1037-1061, (1992)
ROBERT BENEZRA,ROBERT L. DAVIS,ANDREW LASSAR, STEPHEN TAPSCOTT,MATHEW THAYER,DANIEL LOCKSHON,HAROLD WEINTRAUB
Annals of the New York Academy of Sciencesno. 1 Cell Lineages (1990): 1-11
Scienceno. 4984 (1990): 1104-1110
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