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Updated June 2019.
Cytoskeleton: It is now clear that the actin and microtubule cytoskeleton originated in bacteria. Our major research is on FtsZ, the bacterial tubulin homolog, which assembles into a contractile ring that divides the bacterium. We have studied FtsZ assembly in vitro, and found that it assembles into thin protofilaments (pfs). Dozens of these pfs are further clustered to form the contractile Z-ring in vivo. Recent work from other labs has established that the pfs are clustered in small patches that move around the circumference of the cell by a treadmilling mechanism. A major project in our lab is to generate a Monte Carlo model that can explain treadmilling and nucleation, based on conformational changes and GTP hydrolysis. (See my 2019 article on microtubule assembly from flared pfs for a preview of our treadmilling ideas, and an important implication for microtubule assembly.) We are also interested in how FtsZ generates a constriction force, and how this force constricts against turgor pressure, or how it “cheats turgor.”
Irisin. We got interested in irisin from an indirect pathway. We believe the irisin story is bunk. Irisin was proposed in 2012 as a novel myokine: secreted by muscle cells in response to exercise, it induces the transformation of white fat to brown fat. This inspired hopes of an exercise pill that might correct obesity and other metabolic disorders. We have argued that the original discovery was flawed in several respects (Erickson, Adipocyte, 2013), and that the 600+ published follow-up studies are based on flawed commercial antibodies (Albrecht et al, Sci Rep 2015). We are currently using mass spectrometry to measure plasma concentrations of irisin in humans and baboons. This should be interesting because humans have a mutation in the start codon that should reduce its expression ~100x relative to other animals.
研究兴趣
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PRINCIPLES OF PROTEIN-PROTEIN ASSOCIATION (2019)
PRINCIPLES OF PROTEIN-PROTEIN ASSOCIATION (2019)
PRINCIPLES OF PROTEIN-PROTEIN ASSOCIATION (2019)
PRINCIPLES OF PROTEIN-PROTEIN ASSOCIATION (2019)
PRINCIPLES OF PROTEIN-PROTEIN ASSOCIATION (2019)
PRINCIPLES OF PROTEIN-PROTEIN ASSOCIATIONpp.VIII-VIII, (2019)
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Cell reportsno. 13 (2017): 3681-3690
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2017)
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