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Malignant solid tumors contain hypoxic regions due to uncontrolled proliferation of cancer cells and insufficient formation of a vascular network. Accumulating evidence has suggested that hypoxia-inducible factor 1 (HIF-1) functions in not only cellular adaptive response to hypoxia but also malignant progression and chemo-/radio-resistance of cancer cells. However, gene networks responsible for the activation of HIF-1 have not yet been fully elucidated, which makes it difficult to develop novel therapeutic strategies for cancers. We aim at identifying novel HIF-1-related and hypoxia-dependent gene networks and utilizing them as rational targets for cancer therapies.
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IEEE Open Journal of Vehicular Technology (2024): 95-107
CHEMICAL COMMUNICATIONSno. 11 (2024): 1472-1475
BIOLOGY OF THE CELLno. 2 (2024): e2300077-e2300077
crossref(2024)
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2024 IEEE 21ST CONSUMER COMMUNICATIONS & NETWORKING CONFERENCE, CCNCpp.1074-1075, (2024)
IEEE Open Journal of Vehicular Technologyno. 99 (2024): 1-17
crossref(2024)
Peter W. T. Lee,Tatsuya Suwa,Minoru Kobayashi, Hui Yang, Lina R. Koseki, Satoshi Takeuchi,Christalle C. T. Chow, Takaaki Yasuhara,Hiroshi Harada
British Journal of Cancer (2024)
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