基本信息
浏览量:0
职业迁徙
个人简介
Research Interests
Immunity against intracellular, emerging and co-infecting agents.
Key words: T cell responses and memory, bacterial pathogenesis, vaccine.
Description of Research
We have a long-standing interest in basic questions related to generation of effective immune responses, mechanisms of protective immunity, and the establishment of long-term immunological memory. For these basic studies, we have used two well-characterized murine models of infection with lymphocytic choriomeningitis virus (LCMV) and Listeria monocytogenes. More recently, we have become interested in viral/bacterial co-infections, which occur frequently in clinics and often result in more severe disease than infection by an individual pathogen. A striking example of this is the high mortality caused by secondary bacterial pneumonia following flu infection. We are: 1) studying how inflammation induced by a bacterial pathogen may affect the host response to a co-infecting viral pathogen and vice versa, 2) investigating the mechanisms of bacterial pathogenesis that contribute to lethal secondary bacterial pneumonia following flu infection, 3) identifying immune mechanisms and protective antigens that provide immunity against co-infection, and 4) examining how these protective mechanisms may be inhibited during co-infection that leads to high mortality and inadequate immunological memory. Through these studies, we have gained new insights into complexity of tripartite interactions between the virus, bacterium and host immune system. Based on our new findings, we are developing novel, combinational vaccine approaches tailored towards co-infection.
Immunity against intracellular, emerging and co-infecting agents.
Key words: T cell responses and memory, bacterial pathogenesis, vaccine.
Description of Research
We have a long-standing interest in basic questions related to generation of effective immune responses, mechanisms of protective immunity, and the establishment of long-term immunological memory. For these basic studies, we have used two well-characterized murine models of infection with lymphocytic choriomeningitis virus (LCMV) and Listeria monocytogenes. More recently, we have become interested in viral/bacterial co-infections, which occur frequently in clinics and often result in more severe disease than infection by an individual pathogen. A striking example of this is the high mortality caused by secondary bacterial pneumonia following flu infection. We are: 1) studying how inflammation induced by a bacterial pathogen may affect the host response to a co-infecting viral pathogen and vice versa, 2) investigating the mechanisms of bacterial pathogenesis that contribute to lethal secondary bacterial pneumonia following flu infection, 3) identifying immune mechanisms and protective antigens that provide immunity against co-infection, and 4) examining how these protective mechanisms may be inhibited during co-infection that leads to high mortality and inadequate immunological memory. Through these studies, we have gained new insights into complexity of tripartite interactions between the virus, bacterium and host immune system. Based on our new findings, we are developing novel, combinational vaccine approaches tailored towards co-infection.
研究兴趣
论文共 52 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Wenchao Li,Xinyun Zhang, Ying Yang,Qingqin Yin,Yan Wang,Yong Li, Chuan Wang,Sandy M Wong,Ying Wang,Howard Goldfine,Brian J Akerley,Hao Shen
Jin-Zhi Li, Jun Ding, Boukherouba Merim,Hao-Wen Li,Yong Zhang,Hao Shen,Xue-Jin Chen,Shu-Jun Wang,Ying Wang
引用25浏览0WOS引用
25
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn