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The focus of his scientific activities was on the characterization of the development of localized fungal infections of the skin and related mucosal surfaces. He concentrated on secreted aspartic proteases of Candida albicans as virulence factors and toll-like receptors as relevant mediators of the inflammatory host response. It was his prime concern to develop active pharmaceutical ingredients for the treatment and prevention of fungal infections reflecting the increased understanding of pathogenesis. In particular, it was intended to address virulence factors rather than structure and function of the pathogen cell wall according to the motto "targeting virulence: a new paradigm for antifungals". Moreover, he was interested in the development of new biological drugs such as plasmin as well as small molecules which are capable of influencing inflammation in the context of signal transduction such as sphingosine-1-phosphate. In addition, there now was a focus on small molecules modulating the function of human polymerase alpha which at a time modulates proliferation of keratinocytes and various viruses including human papilloma viruses (HPV), which is most relevant in the context of non-melanoma skin cancer treatment.
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American Journal of Clinical Dermatologyno. 5 (2012): 367-368
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