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Imagine walking down a dark street at night. Hearing unexpected footsteps behind you, you feel fear, your heart races, and you get ready to run – all aspects of a complex emotional response. As the example above illustrates, the ability to regulate one’s emotions appropriately in response to such stimuli is crucial for successful and appropriate interaction with our environment. However, abnormal emotional regulation causes major problems and is seen in depression and anxiety disorders. It may result from cognition being abnormally biased by emotive stimuli, and from failure to integrate the behavioural and physiological aspects of emotional responses. However, the neural bases of emotional response integration and cognitive biases are poorly understood.
To do this we combine neuroimaging techniques with specific neurochemical manipulations, telemetric monitoring of cardiovascular responsiveness, and neuropsychological tests that tax cognition and emotion. We combine this with genetic screening and monitoring for proteins involved in emotional responsiveness such as BDNF and cortisol. This information is critical to our understanding of the aetiology of specific symptom clusters within affective and other psychiatric disorders, and may eventually lead to developments in pharmacotherapy better targeted to dysfunctional regions of interest.
To do this we combine neuroimaging techniques with specific neurochemical manipulations, telemetric monitoring of cardiovascular responsiveness, and neuropsychological tests that tax cognition and emotion. We combine this with genetic screening and monitoring for proteins involved in emotional responsiveness such as BDNF and cortisol. This information is critical to our understanding of the aetiology of specific symptom clusters within affective and other psychiatric disorders, and may eventually lead to developments in pharmacotherapy better targeted to dysfunctional regions of interest.
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论文共 27 篇作者统计合作学者相似作者
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eNeuropp.ENEURO.0541-23.2024, (2024)
eNeurono. 3 (2024)
Current Research in Neurobiology (2022): 100049-100049
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