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Apical periodontitis is an inflammatory disease caused by root canal infection. Apical periodontitis is a consequence of highly complex biological processes including (but not limited to) bacterial infection, immune response, bone remodeling, and systemic metabolic disorders. Dr. Sasaki is a dentist-researcher and has been working extensively in the field of apical periodontitis and marginal periodontitis. He aims to integrate various scientific approaches and findings as “dental inflammology" for prevention and cure of dental inflammations. His findings contributed to an understanding of the functional network of immune cells and cytokines (small proteins inducing cell signaling). He currently focuses on the role of damage-associated molecular patterns. He hypothesizes that serum amyloid A (SAA) links dental inflammations and systemic metabolic disorders bidirectionally. In addition, he assesses the importance of hypoxia-inducible factor 1 (HIF-1) in control of inflammation. He recently established a novel mouse model exhibiting HIF-1-mediated spontaneous resolution of inflammation and periapical wound healing. Dr. Sasaki is also positively working on that the science and health professionals and students deepen their understanding of dental inflammology through his research outcomes, publications, and presentations.
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论文共 33 篇作者统计合作学者相似作者
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BMC oral healthno. 1 (2023): 111-111
Biomaterials advances (2023): 213427-213427
Renan Dal-Fabbro, Yu-Chi Huang, Priscila T. A. Toledo,Leticia C. Capalbo,Rhima M. Coleman,Hajime Sasaki,J. Christopher Fenno,Marco C. Bottino
GELSno. 11 (2023): 897-897
Biomaterials advances (2023): 213427-213427
Dental materials : official publication of the Academy of Dental Materialsno. 4 (2023): 333-349
Frontiers in dental medicine (2022)
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