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Hartmut Wekerle investigated the development of autoimmune diseases in the central nervous system (CNS), especially in multiple sclerosis (MS). A focus was on the study of autoimmune lymphocytes - how they are activated in the peripheral immune system, how they find their way into the isolated nervous system and how they finally destroy the brain and spinal cord tissue. With his work, Hartmut Wekerle was able to identify brain reactive autoimmune T lymphocytes in the immune system and, using new imaging approaches, to detail their migration into the brain. More recently, he identified the commensal bacterial gut flora as a factor triggering brain autoimmune disease.
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Isabel J Bauer,Ping Fang, Katrin F Lämmle,Sofia Tyystjärvi,Dominik Alterauge,Dirk Baumjohann, Hongsup Yoon,Thomas Korn,Hartmut Wekerle,Naoto Kawakami
Proceedings of the National Academy of Sciences of the United States of Americano. 30 (2023): e2302697120-e2302697120
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Journal of immunology (Baltimore, Md. : 1950)no. 9 (2017): 3384-3388
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