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Our research specifically examines local mechanisms within the womb-lining (endometrium) involved in menstruation and abnormal uterine bleeding (AUB). Menstruation displays features of an inflammatory event and is a physiological event of repeated "tissue injury and repair" We study the cascade of events that occur in cells of the endometrium and that lead to its shedding. These events are triggered by withdrawal of the hormone, progesterone (P). This occurs at the end of each monthly cycle prior to a period. We are interested in the complex dialogue between circulating steroid hormones and the many different cell types, including immune cells that constitute the endometrium.
We also study factors that switch on production of molecules involved in blood vessel growth and repair in the endometrium; both necessary events to prepare for the next menstrual cycle. If we can understand how the womb heals itself without scarring as women go through their menstrual cycles we hope we will contribute valuable information relevant to inflammation and scarring throughout the body. If these events are disturbed then abnormal menstrual bleeding may be the result. We are therefore studying endometrial samples collected from women attending with menstrual complaints including women with fibroids. We hope that information about the molecular and cellular pathways involved in menstruation will help identify new targets for treatment, especially if these treatments could be delivered directly to the uterus.
Development of novel medical treatments for management of debilitating menstrual complaints aims to enable women to avoid surgery and thereby preserve uterine function and fertility potential.
Our research specifically examines local mechanisms within the womb-lining (endometrium) involved in menstruation and abnormal uterine bleeding (AUB). Menstruation displays features of an inflammatory event and is a physiological event of repeated "tissue injury and repair" We study the cascade of events that occur in cells of the endometrium and that lead to its shedding. These events are triggered by withdrawal of the hormone, progesterone (P). This occurs at the end of each monthly cycle prior to a period. We are interested in the complex dialogue between circulating steroid hormones and the many different cell types, including immune cells that constitute the endometrium.
We also study factors that switch on production of molecules involved in blood vessel growth and repair in the endometrium; both necessary events to prepare for the next menstrual cycle. If we can understand how the womb heals itself without scarring as women go through their menstrual cycles we hope we will contribute valuable information relevant to inflammation and scarring throughout the body. If these events are disturbed then abnormal menstrual bleeding may be the result. We are therefore studying endometrial samples collected from women attending with menstrual complaints including women with fibroids. We hope that information about the molecular and cellular pathways involved in menstruation will help identify new targets for treatment, especially if these treatments could be delivered directly to the uterus.
Development of novel medical treatments for management of debilitating menstrual complaints aims to enable women to avoid surgery and thereby preserve uterine function and fertility potential.
研究兴趣
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Journal of Minimally Invasive Gynecology (2024)
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2023): 27-28
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International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetricsno. S2 (2023): 29-42
K Yin,L Whitaker, E Hojo, S McLenachan,J Walker,G McKillop, C Stubbs, L Priest, M Cruz,N Roberts,H Critchley
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Lucy H.R. Whitaker,Lee J. Middleton,Jane P. Daniels,Alistair R.W. Williams,Lee Priest, Smita Odedra,Versha Cheed,Clive E. Stubbs,T. Justin Clark, Mary-Ann Lumsden,Dharani K. Hapangama,Siladitya Bhattacharya,
EClinicalMedicine (2023): 101995
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eClinicalMedicine (2023): 101995-101995
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetricsno. S2 (2023): 3-6
N. A. M. Cooper,C. Rivas, M. G. Munro,H. O. D. Critchley,T. J. Clark,K. A. Matteson, R. Papadantonaki,S. Yorke,A. Tan, M. Bofill Rodriguez,M. Bongers, A. Al-Hendy,
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