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The long-term goal of the Laboratory of Cancer Immunobiology, led by Hong-Ming Hu, Ph.D., is to understand how the immune system senses tumor cells and develop effective cancer vaccines and immunotherapy strategies. The therapeutic cancer vaccine requires activation and expansion of therapeutic effector T cells in vivo to levels above the threshold required for tumor eradication and prevention of recurrence in tumor-bearing hosts. For most bacterial and viral infections, the robust innate and adaptive immune responses generally result in control of infection and development of a strong memory response. In contrast, for patients with cancer, the host immune system often fails to control the growth of cancer despite the fact that tumor cells replicate at a much slower rate than bacteria and viruses.
The major differences between the immunology of infection and tumors include the following: tumor cells lack strong antigens and, as compared to infections, tumor cells are sensed differently by innate immune system, which orchestrates the subsequent adaptive immune response. The Laboratory of Cancer Immunobiology investigates how tumor cells, live or dead, are sensed by innate immunity and how tumor antigens are cross-presented by host professional antigen presenting cells. Better understanding the mechanisms of early stage of immune recognition of tumor cells would lead to design novel cancer vaccines and immunotherapy strategies.
The major differences between the immunology of infection and tumors include the following: tumor cells lack strong antigens and, as compared to infections, tumor cells are sensed differently by innate immune system, which orchestrates the subsequent adaptive immune response. The Laboratory of Cancer Immunobiology investigates how tumor cells, live or dead, are sensed by innate immunity and how tumor antigens are cross-presented by host professional antigen presenting cells. Better understanding the mechanisms of early stage of immune recognition of tumor cells would lead to design novel cancer vaccines and immunotherapy strategies.
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论文共 154 篇作者统计合作学者相似作者
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Cancer Researchno. 7_Supplement (2024)
Yuhuan Li, Tobias Hahn, Kendra Garrison,Zhi-Hua Cui,Andrew Thorburn,Jacqueline Thorburn,Hong-Ming Hu, Emmanuel T. Akporiaye
crossref(2023)
Marcus A. Couey,Matthew Taylor,Tarsem Moudgil,Yoshinobu Koguchi, Anne Stadum, Tanisha Christie,William L. Redmond,Christopher Paustian,Ryan Meng,Venkatesh Rajamanickam,Lessli Rushforth, Abigail Peterson,
CANCER RESEARCHno. 8 (2023)
Yuhuan Li, Tobias Hahn, Kendra Garrison,Zhi-Hua Cui,Andrew Thorburn,Jacqueline Thorburn,Hong-Ming Hu, Emmanuel T. Akporiaye
crossref(2023)
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
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Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
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Henry Yu,Hong-Ming Hu,Rongliang Lou,Wanping Geng, Sanlong Wang,William Redmond,Yoshinobu Koguchi,Baotian Qin,John Mao, Shaoshan Wang
Regular and Young Investigator Award Abstracts (2022): A1214-A1214
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Rom S. Leidner,Matthew H. Taylor,Tarsem Moudgil, Tanisha Christie,Yoshinobu Koguchi,Alexa K. Dowdell,William L. Redmond,Shawn M. Jensen,Carmen Ballesteros-Merino, Jake A. Vancampen,Venkatesh Rajamanickam,Brady Bernard,
Cancer Researchno. 12_Supplement (2022): CT502-CT502
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