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职业迁徙
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Our main goal is to improve immunotherapy for cancer patients by using translational in vitro and in vivo tumor models, performing correlative analysis of patients treated with immunotherapy and conducting early clinical interventional trials (also see link to Medical Oncology).
One of our research focus is on the role of glycans and glycan-binding receptors in anti-cancer immunity. Glycans can mediate important interactions with immune cells and manipulation of glycans and glycan-binding receptors (lectins) bear a great potential to improve anti-tumor immune reactions. Glycan-mediated interactions in cancer immunology are significantly underexplored and could be used to improve anti-cancer immunity. Our group has studied the interaction between glycans that contain sialic acids (siaologlycans) and their interaction with Siglec receptors on immune cells and have demonstrated that this pathway can be targeted to augment T cell stimulation and tumor control. Current goals include improvement of cancer immunotherapy by modifying glycans in the tumor microenvironment and glycans of cellular products for adoptive cell therapies including genetically modified T cells.
An additional focus of our group is the improvement of immune checkpoint blockade and adoptive cellular therapies by investigating mechanisms and patterns of resistance to these therapies. To this end, we are investigating the tumor microenvironment as well as circulating immune cells in patients undergoing immune checkpoint blockade or adoptive T cell transfer. Identified pathways are further studied in the laboratory for their potential as new targets to improve antitumor immune responses.
One of our research focus is on the role of glycans and glycan-binding receptors in anti-cancer immunity. Glycans can mediate important interactions with immune cells and manipulation of glycans and glycan-binding receptors (lectins) bear a great potential to improve anti-tumor immune reactions. Glycan-mediated interactions in cancer immunology are significantly underexplored and could be used to improve anti-cancer immunity. Our group has studied the interaction between glycans that contain sialic acids (siaologlycans) and their interaction with Siglec receptors on immune cells and have demonstrated that this pathway can be targeted to augment T cell stimulation and tumor control. Current goals include improvement of cancer immunotherapy by modifying glycans in the tumor microenvironment and glycans of cellular products for adoptive cell therapies including genetically modified T cells.
An additional focus of our group is the improvement of immune checkpoint blockade and adoptive cellular therapies by investigating mechanisms and patterns of resistance to these therapies. To this end, we are investigating the tumor microenvironment as well as circulating immune cells in patients undergoing immune checkpoint blockade or adoptive T cell transfer. Identified pathways are further studied in the laboratory for their potential as new targets to improve antitumor immune responses.
研究兴趣
论文共 158 篇作者统计合作学者相似作者
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Chih-Wei Chu,Tomislav Caval,Frederico Alisson-Silva, Akshaya Tankasala,Christina Guerrier, Gregg Czerwieniec,Heinz Laubli,Flavio Schwarz
bioRxiv (Cold Spring Harbor Laboratory)no. 3 (2024)
Eveline Daetwyler, Till Wallrabenstein,David Koenig,Laura C. Cappelli, Jarushka Naidoo, Alfred Zippelius,Heinz Laeubli
JOURNAL FOR IMMUNOTHERAPY OF CANCERno. 1 (2024)
BMC Cancerno. 1 (2024): 1-7
Kim Boesen,Julian Hirt, Pascal Dueblin,Heinz Laubli, Benjamin Kassenda,Lars G Hemkens,Perrine Janiaud
crossref(2024)
Ronja Wieboldt, Michael Sandholzer, Emanuele Carlini,Chia-wei Lin, Anastasiya Börsch,Andreas Zingg,Didier Lardinois,Petra Herzig, Leyla Don,Alfred Zippelius,Heinz Läubli,Natalia Rodrigues Mantuano
Cellular & Molecular Immunologypp.1-15, (2024)
Filip Filipsky,Heinz Läubli
Ronja Wieboldt, Michael Sandholzer, Emanuele Carlini,Chia-wei Lin, Anastasiya Börsch, Andreas Zingg,Didier Lardinois,Petra Herzig, Leyla Don,Alfred Zippelius,Heinz Läubli,Natalia Rodrigues Mantuano
Immuno-Oncology and Technology (2024): 1-15
BMC CANCERno. 1 (2024)
Ignacio Melero, María de Miguel Luken, Guillermo de Velasco,Elena Garralda, Juan Martin Liberal,Markus Joerger,Guzman Alonso, Maria-Elizabeth Goebeler,Martin Schuler, David König,Reinhard Dummer, Mara Reig,
crossref(2024)
Nina Wyss,Fiamma Berner,Vincent Walter, Ann-Kristin Jochum, Mette T Purde,Marie-Therese Abdou,Tobias Sinnberg, Kathrin Hofmeister,Oltin T Pop,Omar Hasan Ali,Jens Bauer,Hung-Wei Cheng,
American journal of respiratory and critical care medicine (2024)
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