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The name Horst Kessler is most closely associated with “conformational analysis of peptides, in particular cyclical peptides”. In his work, Horst Kessler linked design to synthetic works, spectroscopic examination and molecular dynamics computations. These methods are now recognized as key processes for the development of new active substances. The question of directed influence of pharmacologically active conformation through ring formation led Horst Kessler to the field of cancer research. Some of the results of his basic research found their way into practice, such as the development of medicines to treat brain tumors or other cancers, the improvement of hip implants and early discovery and characterization of cancer metastases through molecular imaging. Horst Kessler contributed important methodological developments on nuclear magnetic resonance spectroscopy (NMR). In the last two decades, Horst Kessler applied these methods to proteins as well: for example, tumor suppressor protein p53 and its interaction partners as well as various heat shock proteins. His elucidation of terminal domains of spider silk protein, which explains the creation of extremely stable filament spun from the storage form, attracted great interest. He has received international recognition for his scientific and academic wor
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Amelie Bauer, Matteo Puglisi,Dennis Nagl,Joel A Schick,Thomas Werner, Andreas Klingl,Jihad El Andari,Veit Hornung,Horst Kessler,Magdalena Götz,Dirk Grimm,Ruth Brack-Werner
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