基本信息
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职业迁徙
个人简介
RESEARCH INTERESTS :
Discovery, development and validation of novel therapies and multimodal biomarker candidates using biochemical (blood & CSF) and structural, functional & metabolic neuroimaging methods in mono- and multi-site studies for risk assessment, progression, prediction, detection, diagnosis and classification of neurodegenerative diseases (focus on Alzheimer's disease [AD]) at different disease stages. Detection of genetic risk & protection variants in large-scale international research networks.
CONCEPTUAL AND RESEARCH FRAMEWORK:
(1) the emergence of the network paradigm, due in large part to neuroimaging; instead of thinking of the brain as a set of modules (i.e., individual brain regions) that perform specific cognitive functions, the network paradigm argues that cognitive functions are performed by dynamic interactions among different brain areas - i.e., by dynamically formed functional networks of brain regions; and
(2) the emergence of neural modeling required by the network paradigm, since to deal with the complexity of the dynamic interactions among multiple brain regions, one must employ computational methods.
(3) the emergence of the systems biology paradigm. Systems biology represents an integrated and deeper investigation of interacting biomolecules within cells or organisms. This approach has only recently become feasible as high-throughput technologies including cDNA microarrays, mass spectrometric analyses of proteins and lipids together with rigorous bioinformatics have evolved. High-content data point to convergent pathways among neurodegenerative diseases, which transcend descriptive studies to reach a more integrated understanding of disease pathogenesis and, in some instances, highlighting ‘druggable’ network nodes.
研究兴趣
论文共 1089 篇作者统计合作学者相似作者
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Viswanath Devanarayan, Yuanqing Ye, Arnaud Charil, Erica Andreozzi,Pallavi Sachdev,Daniel A. Llano,Lu Tian, Liang Zhu,Harald Hampel,Lynn Kramer,Shobha Dhadda,Michael Irizarry
Journal of Alzheimer's Diseasepp.1-15, (2024)
Neurobiology of aging (2024): 62-77
Maria Soto,P. Rosenberg, C. Ballard,B. Vellas, D. Miller,S. Gauthier,M. C. Carrillo, C. Lyketsos, Z. Ismail,Susan Abushakra, Mohammad Afshar, Sam Agus,
D. Angioni,O. Hansson, R. J. Bateman, C. Rabe, M. Toloue, J. B. Braunstein, S. Agus,J. R. Sims, T. Bittner, M. C. Carrillo, H. Fillit,C. L. Masters,
The journal of prevention of Alzheimer's diseaseno. 3 (2023): 418-425
Alzheimer's research & therapyno. 1 (2023): 1-11
Clinical Neurophysiology (2023): e74-e75
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