基本信息
浏览量:91
职业迁徙
个人简介
Research
Cancer of the head and neck is the sixth most common cancer worldwide. Although therapy concepts have been improved during the past decades, the survival rate still only is about 50%. Radiation therapy plays an important role in the definitive therapy of head and neck squamous cells carcinoma (HNSCC), both as adjuvant treatment after surgery and as primary treatment (possibly combined with chemotherapy). The tumour response to radiation treatment exhibits, however, large inter-individual differences. Some tumours apparently have intrinsic protective mechanisms that make them resistant to the radiation doses normally applied during therapy. On the other hand, the side effects associated with radiation therapy do not allow a general enhancement of treatment doses. Thus, the identification of radiation resistant tumours prior to therapy would be very helpful in order to provide patients with improved personalised treatment strategies.
In previous work, scientists from the Research Unit of Radiation Cytogenetics at the Helmholtz Zentrum München identified chromosomal alterations in head and neck tumours that were associated with poor survival in patients treated with radiotherapy. In co-operation with the Department of Radiation Oncology of the KUM University Hospital, these potential markers of therapy response in HNSCC will now be validated in independent retrospective tumour sets. In collaboration with the Department of Otorhinolaryngology of the KUM University Hospital we also will establish a patient cohort for prospective validation. Besides validating candidate markers, we will additionally search for new markers of radiation sensitivity and of tumour therapy response. Therefore, tumour tissue obtained at surgery or biopsy will be analysed using genome-wide screening methods at different molecular levels and the resulting tumour-related alterations will be tested for a correlation with the clinical data including the follow-up data.
Cancer of the head and neck is the sixth most common cancer worldwide. Although therapy concepts have been improved during the past decades, the survival rate still only is about 50%. Radiation therapy plays an important role in the definitive therapy of head and neck squamous cells carcinoma (HNSCC), both as adjuvant treatment after surgery and as primary treatment (possibly combined with chemotherapy). The tumour response to radiation treatment exhibits, however, large inter-individual differences. Some tumours apparently have intrinsic protective mechanisms that make them resistant to the radiation doses normally applied during therapy. On the other hand, the side effects associated with radiation therapy do not allow a general enhancement of treatment doses. Thus, the identification of radiation resistant tumours prior to therapy would be very helpful in order to provide patients with improved personalised treatment strategies.
In previous work, scientists from the Research Unit of Radiation Cytogenetics at the Helmholtz Zentrum München identified chromosomal alterations in head and neck tumours that were associated with poor survival in patients treated with radiotherapy. In co-operation with the Department of Radiation Oncology of the KUM University Hospital, these potential markers of therapy response in HNSCC will now be validated in independent retrospective tumour sets. In collaboration with the Department of Otorhinolaryngology of the KUM University Hospital we also will establish a patient cohort for prospective validation. Besides validating candidate markers, we will additionally search for new markers of radiation sensitivity and of tumour therapy response. Therefore, tumour tissue obtained at surgery or biopsy will be analysed using genome-wide screening methods at different molecular levels and the resulting tumour-related alterations will be tested for a correlation with the clinical data including the follow-up data.
研究兴趣
论文共 153 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Julia Hess,Kristian Unger,Cornelius Maihoefer, Lars Schüttrumpf,Ludmila Wintergerst,Theresa Heider,Peter Weber,Sebastian Marschner,Herbert Braselmann,Daniel Samaga, Sebastian Kuger,Ulrike Pflugradt,
crossref(2023)
J Hess, K Unger, C Maihoefer, L Schuettrumpf,L Schneider,T Heider,P Weber,S Marschner,H Braselmann,S Kuger, U Pflugradt,P Baumeister,
引用0浏览0引用
0
0
Xiao Liu,Junjian Li,Bruno Loureiro Cadilha, Anamarija Markota,Cornelia Voigt,Zhe Huang,Peter P Lin,Daisy D Wang,Juncheng Dai,Gisela Kranz, Anna Krandick,Darko Libl,
Claudia Dalke,Frauke Neff, Savneet Kaur Bains,Scott Bright, Deborah Lord, Peter Reitmeir,Ute Rößler,Daniel Samaga,Kristian Unger,Herbert Braselmann,Florian Wagner,Matthias Greiter,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn