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We (GSB) have contributed over the past several years in understanding the characteristics of the cell wall of TB, which has been the site of action of a number of front-line TB agents. We have now opted for a broader strategy: identification of new drug targets and drug development (with Professor Minnikin); vaccine development; identification of mechanisms of intracellular survival, replication and pathogenesis; definition of the fundamental genome of the tubercle bacillus, its phenotype and the functionality of the phenotypic characteristics through derivation of mutants.
It is a widely held view that efforts to relieve the disease burden imposed by tuberculosis must benefit from concerted attempts to understand the basic biochemistry of the organism, particularly in view of the current availability genomic data from the M. Tuberculosis genome. Thus, providing a timely insight into these remarkable bacteria and several novel areas of mycobacterial cell wall physiology
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The Cell Surface (2024): 100122-100122
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ChemMedChem (2023)
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Tuberculosis (Edinburgh, Scotland) (2023): 102420-102420
Andrew Chancellor, Robert Alan Simmons, Rahul C Khanolkar,Vladimir Nosi, Aisha Beshirova, Giuliano Berloffa, Rodrigo Colombo,Vijaykumar Karuppiah,Johanne M Pentier, Vanessa Tubb,Hemza Ghadbane, Richard J Suckling,
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