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Research Overview:
Our laboratory focuses on engineering intelligent biomaterials for drug delivery, with the ultimate goal towards precision medicine. We are also interested in understanding and exploiting the interactions between biomaterials and biological systems for therapeutic applications. Our research is being conducted in a multidisciplinary and collaborative environment, bridging engineering with materials science, chemistry, biology, and health sciences. Specific research directions are:
Cold atmospheric plasma-mediated cancer immunotherapy: Cold atmospheric plasma (CAP), an ionized gas composed of charged species, radicals, and photons, generates at atmospheric pressure/room temperature and has demonstrated great promise for many biomedical applications, including cancer treatment. Our research in this line will focus on developing strategies for CAP delivery and synergizing CAP therapy with cancer immunotherapy. We will also discover the underlying fundamental knowledge of CAP on immune systems.
Biomaterials-mediated cancer immunotherapy: Biomaterials-mediated modulation of immune systems has emerged as a promising solution for treating immune-dysfunction-related diseases. We focus on design and leverage biomaterials to reprogram the immune environments for treating diseases such as cancer.
Non-viral genome editing: Genome editing offers promising solutions to treat many genetic disorders by correcting DNA sequences or regulating gene expression. However, the delivery of active genome-editing machineries, such as CRISPR/Cas9 components, into target cells/tissues in vivo remains a challenge. We aim to design delivery systems to achieve precise and efficient genome editing for disease treatment.
Our laboratory focuses on engineering intelligent biomaterials for drug delivery, with the ultimate goal towards precision medicine. We are also interested in understanding and exploiting the interactions between biomaterials and biological systems for therapeutic applications. Our research is being conducted in a multidisciplinary and collaborative environment, bridging engineering with materials science, chemistry, biology, and health sciences. Specific research directions are:
Cold atmospheric plasma-mediated cancer immunotherapy: Cold atmospheric plasma (CAP), an ionized gas composed of charged species, radicals, and photons, generates at atmospheric pressure/room temperature and has demonstrated great promise for many biomedical applications, including cancer treatment. Our research in this line will focus on developing strategies for CAP delivery and synergizing CAP therapy with cancer immunotherapy. We will also discover the underlying fundamental knowledge of CAP on immune systems.
Biomaterials-mediated cancer immunotherapy: Biomaterials-mediated modulation of immune systems has emerged as a promising solution for treating immune-dysfunction-related diseases. We focus on design and leverage biomaterials to reprogram the immune environments for treating diseases such as cancer.
Non-viral genome editing: Genome editing offers promising solutions to treat many genetic disorders by correcting DNA sequences or regulating gene expression. However, the delivery of active genome-editing machineries, such as CRISPR/Cas9 components, into target cells/tissues in vivo remains a challenge. We aim to design delivery systems to achieve precise and efficient genome editing for disease treatment.
研究兴趣
论文共 128 篇作者统计合作学者相似作者
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Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
crossref(2024)
Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
crossref(2024)
Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
crossref(2024)
Fan Bai,Yueyang Deng,Long Li, Ming Lv,Jamoliddin Razzokov, Qingnan Xu, Zhen Xu,Zhaowei Chen,Guojun Chen,Zhitong Chen
Exploration (2024)
Advanced Materialsno. 13 (2024)
Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
crossref(2024)
BIOACTIVE MATERIALS (2024): 530-542
Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
crossref(2024)
ADVANCED MATERIALSno. 13 (2024)
Xiaona Cao, Tianxu Fang, Mo Chen, Tianqin Ning,Jianyu Li,Peter Siegel,Morag Park,Zhitong Chen,Guojun Chen
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