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In order to characterize the tasks and functioning of nuclear receptors, Schütz and his co-workers silenced the genes of these receptors in mice. The researchers then studied the effects of this loss in the animals. However, since mice are often not viable if these important receptors are missing, Schütz developed sophisticated molecular-biological methods to switch off receptor genes very selectively only in specific cell types and under specific conditions.
Thus, Schütz was able to elucidate, among other things, how nuclear receptors regulate embryonic and neural development and how sexual hormones influence brain functioning. He has studied the molecular foundations of learning and remembering, drug addiction, and – in his most recent work – key molecules responsible for the development of brain tumors. “Our research continues to be very exciting,” says Schütz, “because it often happens that we come across new, unexpected results.”
Thus, Schütz was able to elucidate, among other things, how nuclear receptors regulate embryonic and neural development and how sexual hormones influence brain functioning. He has studied the molecular foundations of learning and remembering, drug addiction, and – in his most recent work – key molecules responsible for the development of brain tumors. “Our research continues to be very exciting,” says Schütz, “because it often happens that we come across new, unexpected results.”
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Biochemical and biophysical research communicationsno. 1 (2020): 209-214
semanticscholar(2019)
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semanticscholar(2018)
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Silvia León,Alexia Barroso, María J Vázquez,David García-Galiano,María Manfredi-Lozano, Francisco Ruiz-Pino,Violeta Heras,Antonio Romero-Ruiz, Juan Roa,Günther Schutz, Milen Kirilov,Francisco Gaytan,
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