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During his doctoral work, Dr. García-Cardeña characterized multiple mechanisms, including covalent modification and subcellular distribution of key proteins, crucial for the regulation of endothelial nitric oxide synthase. These studies identified several novel targets for the regulation of NO production in the vascular system. As a postdoctoral trainee, he undertook investigation of endothelial cell responsiveness to various forms of biomechanical perturbation and their functional consequences for endothelial phenotype. These studies involved the development of high-throughput transcriptional profiling platforms to analyze global gene expression patterns in endothelial cells, as well as the creation of novel devices to simulate in vitro the endothelium under shearing blood flow.
研究兴趣
论文共 98 篇作者统计合作学者相似作者
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Jia He,Adriana Blazeski, Uthayanan Nilanthi,Javier Menéndez, Samuel C Pirani,Daniel S Levic,Michel Bagnat, Manvendra K Singh, José G Raya,Guillermo García-Cardeña,Jesús Torres-Vázquez
bioRxiv : the preprint server for biology (2024)
Alessandro Arduini,Stephen J Fleming,Ling Xiao,Amelia W Hall,Amer-Denis Akkad,Mark Chaffin, Kayla J Bendinelli,Nathan R Tucker,Irinna Papangeli, Helene Mantineo,Mehrtash Babadi,Christian M Stegmann,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Jules D. Allbritton-King,Guillermo Garcia-Cardena
Frontiers in Cell and Developmental Biology (2023): 1278166-1278166
Adriana Blazeski,Marie A. Floryan, Oscar R. Fajardo-Ramírez,Elamaran Meibalan, Jesús Ortiz-Urbina, Emmanouil Angelidakis,Sarah E. Shelton,Roger D. Kamm,Guillermo García-Cardeña
bioRxiv : the preprint server for biology (2023)
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Rebeccah J. Luu, B. Christopher Hoefler,Ashley L. Gard, Casey R. Ritenour,Miles T. Rogers,Ernest S. Kim,Jonathan R. Coppeta,Brian P. Cain,Brett C. Isenberg,Hesham Azizgolshani, Oscar R. Fajardo-Ramirez,Guillermo Garcia-Cardena,
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Suvi Linna-Kuosmanen,Eloi Schmauch, Kyriakitsa Galani,Carles A. Boix,Lei Hou,Tiit Örd,Anu Toropainen,Lindsey K. Stolze,Elamaran Meibalan,Julio C. Mantero, Ashley Renfro, Johannes Ojanen,
biorxiv(2021)
Suvi Linna-Kuosmanen,Eloi Schmauch,Kyriaki Galani,Carles Boix,Lei Hou, Örd T,Anu Toropainen, Stolze Lk,Elamaran Meibalan, Mantero Jc, Ashley Renfro, Johannes Ojanen,
bioRxiv (Cold Spring Harbor Laboratory) (2021)
Blood advancesno. 13 (2020): 2851-2864
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