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Dr. Hare's long-term research goal is to define mechanisms of anemia-induced morbidity and mortality; and to design novel treatment strategies to prevent these adverse outcomes. His research is focused on defining adaptive, and maladaptive, cardiovascular mechanisms in experimental models of acute anemia using integrative whole animal models. These translational studies have defined mechanism of anemia-induced tissue hypoxia and mortality. Dr. Hare’s laboratory has identified integrative adaptive cellular (nNOS and HIF) and physiological mechanisms, which promote organism survival during acute anemia. In addition, their laboratory has demonstrated that acute beta-blockade interferes with adaptive cardiovascular mechanisms, which sustain cerebral oxygen delivery during anemia-possibly explaining the negative interaction between acute anemia and beta-blockade and the increased incidence of stroke in perioperative patients. The laboratory is currently focused on translational approaches to identify patient specific biomarkers of anemia-induced tissue hypoxia in order to identify when patients are at risk of anemia induced morbidity and mortality; and to derive patient specific therapies which can reduce morbidity and mortality associated with both anemia and red blood cell transfusion. The overall clinical goal is to reduce morbidity and mortality associated with acute and chronic anemia in perioperative patients.
Dr. Hare's long-term research goal is to define mechanisms of anemia-induced morbidity and mortality; and to design novel treatment strategies to prevent these adverse outcomes. His research is focused on defining adaptive, and maladaptive, cardiovascular mechanisms in experimental models of acute anemia using integrative whole animal models. These translational studies have defined mechanism of anemia-induced tissue hypoxia and mortality. Dr. Hare’s laboratory has identified integrative adaptive cellular (nNOS and HIF) and physiological mechanisms, which promote organism survival during acute anemia. In addition, their laboratory has demonstrated that acute beta-blockade interferes with adaptive cardiovascular mechanisms, which sustain cerebral oxygen delivery during anemia-possibly explaining the negative interaction between acute anemia and beta-blockade and the increased incidence of stroke in perioperative patients. The laboratory is currently focused on translational approaches to identify patient specific biomarkers of anemia-induced tissue hypoxia in order to identify when patients are at risk of anemia induced morbidity and mortality; and to derive patient specific therapies which can reduce morbidity and mortality associated with both anemia and red blood cell transfusion. The overall clinical goal is to reduce morbidity and mortality associated with acute and chronic anemia in perioperative patients.
研究兴趣
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TRANSFUSIONno. 11 (2023): 2013-2016
Makoto Hibino,Mark D. Peterson, Ricardo Tachibana,Michael W.A. Chu,John Bozinovski,François Dagenais,Adrian Quan,Fábio de Vasconcelos Papa,Jeffrey Dickson,Hwee Teoh, Ahmad Alli,Gregory M.T. Hare,
The Annals of thoracic surgeryno. 3 (2023): 627-633
Brian A. Pollard, Celine Meschino,Bijan Teja,Gregory M. T. Hare, Yekta Soleimani Jobaneh, Chloe Butler, Ryan Khan,Jeremy Hall,Timothy Daniels
Kyle Chin,Hannah Joo, Helen Jiang, Chloe Lin,Iryna Savinova, Sarah Joo,Ahmad Alli,Michael C Sklar, Fabio Papa,Jeremy Simpson,Andrew J Baker,C David Mazer,
Nikhil Mistry,Greg Hare,Nadine Shehata, Fabio Papa, Robert S. Kramer,Tarit Saha,Subodh Verma, David Mazer
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