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Gregorio Weber was responsible for many of the more important theoretical and experimental developments in modern fluorescence spectroscopy. In particular, he pioneered the application of fluorescence spectroscopy to the biological sciences. His list of achievements includes the following:
the synthesis and use of dansyl chloride as a probe of protein hydrodynamics;
the extension of Perrin’s theory of fluorescence polarization to fluorophores associated with random orientations with ellipsoids of revolution and to mixtures of fluorophores;
the first spectral resolution of the fluorescence of the aromatic amino acids and of intrinsic fluorescence of proteins; the first demonstration that both FAD and NADH make internal complexes;
the first report on aromatic secondary amines, which are strongly fluorescent in apolar solvents, but hardly in water, the most spectacular case being the anilino naphthalene sulfonates (ANS);
the first description of the use of the fluorescence of small molecules as probes for the viscosity of micelles, with implications for membrane systems; a general formulation of depolarization by energy transfer;
the discovery of the “red-edge” effect in homo-energy transfer;
the development of modern cross-correlation phase fluorometry;
the development of the excitation-emission matrix method for resolving contributions from multiple fluorophores;
the synthesis of several novel fluorophores, including pyrenebutyric acid, IAEDANS, bis-ANS, PRODAN and LAURDAN, designed to probe dynamic aspects of biomolecules.
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论文共 47 篇作者统计合作学者相似作者
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HIGH PRESSURE CHEMISTRY, BIOCHEMISTRY AND MATERIALS SCIENCE (1993): 471-487
HIGH PRESSURE CHEMISTRY, BIOCHEMISTRY AND MATERIALS SCIENCE (1993): 489-509
Retrospect and Prospect of Protein Researchpp.221-225, (1991)
Biometalsno. 2 (1990): 127-130
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