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Our research group studies structure-mechanical property relationships of calcified tissues (bone, cementum, dentin, enamel). The main functions of these biological materials are mechanical, but much work is needed to understand how their unique and versatile properties are derived based on combinations of protein and mineral. We seek insight into biomineralization processes associated with these tissues during development, alterations resulting from disease, or repair and regeneration from clinical treatments. We also focus on natural interfaces between various calcified tissues and artificial interfaces between the tissues and artificial materials, e.g., dental restorations, implants, bioactive substrates. We use a wide variety of approaches including atomic force microscopy (AFM; and AFM-based nano-indentation) as well as other high resolution imaging methods and participate in wide-ranging collaborations in the Bay Area. This work helps define alteration in properties and structure with hydration state, mineral level, and variations induced by disease and physiological processes. This information is needed to develop a composite structural model of calcified tissues and can assist in the development of bioinspired materials and tissue engineering.
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Natalie B Hastings, Linda S Centore,Stuart A Gansky, Frederick C Finzen,Joel M White,Eric Wong,Grayson W Marshall,Lisa Chung,Elsbeth Kalenderian
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