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个人简介
Dr Theron’s research is on the diagnosis of TB and the transmission of TB. Both under-diagnosis and person-to-person transmission (including for drug-resistant TB) are likely the two biggest drivers of the TB epidemic (TB is, in the applicant’s home country of South Africa, the single biggest cause of death). Dr Theron conducts both applied and basic research on TB diagnostics where, for example, the diagnostic accuracy and utility of new tools is assessed in large patient cohorts or, as in funded by this fellowship, new biomarkers for discriminating active cases from symptomatic patients are identified. His work on transmission involves characterising the infectiousness of TB patients by quantifying their respirable aerosol containing culturable Mycobacterium tuberculosis bacteria. Of relevance to this fellowship, he is also analysing the blood from patients that are highly infectiousness to see if signatures associated with active TB disease are also useful for identifying highly infectious patients. The potential impact of this work is that (1) it provides evidence to support the implementation of new diagnostic tools in high TB burden countries (several of Dr Theron’s publications have been cited in international policy documents), and (2) facilitates the development of new point-of-care tools (that are not dependent on difficult specimen types like sputum) for the diagnosis of TB. Collectively, this will contribute to the better diagnosis of TB (only half of cases are currently thought to be diagnosed) and the identification of highly infectious patients (which can then be triaged or targeted for interventions to reduce their infectiousness). From a societal perspective, alleviating the burden of TB will reduce the high rates of mortality, scale, and catastrophic economic impact associated with the disease.
研究兴趣
论文共 188 篇作者统计合作学者相似作者
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Sophie Huddart, Vijay Yadav,Solveig K Sieberts, Larson Omberg, Mihaja Raberahona, Rivo Rakotoarivelo, Issa N Lyimo,Omar Lweno, Devasahayam J Christopher,Nguyen Viet Nhung,Grant Theron,William Worodria,
medRxiv : the preprint server for health sciences (2024)
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medrxiv(2024)
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The Lancet Global Health (2024)
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Alberto L Garcia-Basteiro,Joanna Ehrlich, Maryline Bonnet,Marianne Calnan, Stephen M Graham, Sabine Hermans, Adriana Jarrett, Rhoda Lewa,Anna Mandalakas, Leonardo Martinez,Giovanni Battista Migliori, Catherine W M Ong,
The Lancet Global Healthno. 5 (2024): e737-e739
Tiffeney Mann,Rishi K Gupta,Byron W P Reeve,Gcobisa Ndlangalavu,Aneesh Chandran, Amirtha P Krishna,Claire J Calderwood, Happy Tshivhula,Zaida Palmer,Selisha Naidoo, Desiree L Mbu,Grant Theron,
Byron W P Reeve,Gcobisa Ndlangalavu,Hridesh Mishra,Zaida Palmer, Happy Tshivhula,Loren Rockman,Selisha Naidoo, Desiree L Mbu,Charissa C Naidoo,Brigitta Derendinger,Gerhard Walzl,Stephanus T Malherbe,
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Byron W P Reeve,Gcobisa Ndlangalavu,Hridesh Mishra,Zaida Palmer, Happy Tshivhula,Loren Rockman,Selisha Naidoo, Desiree L Mbu,Charissa C Naidoo,Brigitta Derendinger,Gerhard Walzl,Stephanus T Malherbe,
The Lancet Global Health (2024)
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medRxiv : the preprint server for health sciences (2023)
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