基本信息
浏览量:2
职业迁徙
个人简介
Our research harnesses the chemistry of venoms from arthropod predators, such as spiders, scorpions and centipedes, to develop novel pharmaceuticals to treat chronic pain, epilepsy and stroke. Stroke is the second-leading cause of death worldwide. In addition, it causes an extremely high incidence of disability in surviving victims due to the brain damage suffered during stroke. Likewise, chronic pain is a huge medical problem that affects one in five adults. There are few drugs available for treating chronic pain, and many of these have limited efficacy and dose-limiting side effects. Animal venoms are a rich source of stable natural peptides that potently modulate the activity of a wide range of neuronal ion channels and receptors. We have the largest collection of arthropod venoms in the world, a high-throughput pipeline for venoms-based drug discovery, protocols for rapid protein expression and structure determination, and links to key laboratories for testing the efficacy of lead molecules in rodent models of pain, epilepsy and stroke. We are using these world-class resources to move us closer to achieving our aim of developing novel analgesics for pain relief, novel drugs for treating severe paediatric epilepsies, and novel neuroprotective agents for treating stroke victims. An equally important focus of our research is on helping to safeguard Australia’s agricultural crops and reduce the spread of disease from insect pests by discovering new environmentally friendly insecticides. Currently, arthropod pests destroy approximately 15 per cent of the world’s food supply and spread pernicious diseases such as dengue and malaria. Our work is finding better, safer ways to control disease-spreading pests and protect crops.
研究兴趣
论文共 351 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Simon Kramer, Charan Kotapati, Yuanzhao Cao,Bryan G. Fry,Nathan J. Palpant,Glenn F. King,Fernanda C. Cardoso
TOXICON-X (2024): 100184-100184
The Journal of biological chemistryno. 1 (2024): 105577-105577
Adriana Knezic, Elena Budusan,Natalie J. Saez, Brad R. S. Broughton,Lachlan D. Rash,Glenn F. King,Robert E. Widdop,Claudia A. Mccarthy
bioRxiv : the preprint server for biology (2024)
crossref(2024)
Samantha C Salvage,Taufiq Rahman,David A Eagles,Johanna S Rees,Glenn F King,Christopher L-H Huang, Antony P Jackson
Journal of cellular physiologyno. 6 (2023): 1354-1367
Journal of Cellular Physiologyno. 6 (2023): 1354-1367
引用0浏览0引用
0
0
Shirin Ahmadi, Melisa Benard-Valle,Kim Boddum,Fernanda C Cardoso,Glenn F King,Andreas Hougaard Laustsen,Anne Ljungars
Frontiers in pharmacology (2023): 1249336-1249336
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn