基本信息
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职业迁徙
个人简介
My Research
KEYWORDS
protein dynamics, molecular machines, cellular motility, cryo electron microscopy, structural biology, structure-dynamics-function relationships, motor proteins, lipid trafficking, host-parasite interactions, microbes, parasites, multi-scale imaging, pathogens
SUMMARY
From atoms to cells to organisms, life is in constant motion. Every cell faces the challenge of transporting molecules from one location to another within the cell, a process that is essential for normal function. Proteins that are responsible for proper transport range from simple globular proteins to large multi-protein complexes. In our lab, we use a hybrid approach to study the structural mechanisms of how macromolecular protein machines are spectacularly coordinated to facilitate transport in normal cells, and what goes wrong when they break.
We are interested in understanding how protein structure, function, and dynamics are coordinated in biological systems. We use structural biology techniques such as cryo-electron microscopy and X-ray crystallography, in combination with biochemistry, functional assays and cell biology, to study complex macromolecular machines in cells. Our questions are centered on microbes and pathogens.
KEYWORDS
protein dynamics, molecular machines, cellular motility, cryo electron microscopy, structural biology, structure-dynamics-function relationships, motor proteins, lipid trafficking, host-parasite interactions, microbes, parasites, multi-scale imaging, pathogens
SUMMARY
From atoms to cells to organisms, life is in constant motion. Every cell faces the challenge of transporting molecules from one location to another within the cell, a process that is essential for normal function. Proteins that are responsible for proper transport range from simple globular proteins to large multi-protein complexes. In our lab, we use a hybrid approach to study the structural mechanisms of how macromolecular protein machines are spectacularly coordinated to facilitate transport in normal cells, and what goes wrong when they break.
We are interested in understanding how protein structure, function, and dynamics are coordinated in biological systems. We use structural biology techniques such as cryo-electron microscopy and X-ray crystallography, in combination with biochemistry, functional assays and cell biology, to study complex macromolecular machines in cells. Our questions are centered on microbes and pathogens.
研究兴趣
论文共 107 篇作者统计合作学者相似作者
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ELIFE (2024)
Shoshanna C Kahne, Jin Hee Yoo,James Chen, Kehilwe Nakedi,Lakshminarayan M Iyer,Gregory Putzel, Nora M Samhadaneh,Alejandro Pironti,L Aravind,Damian C Ekiert,Gira Bhabha,Kyu Y Rhee,
bioRxiv : the preprint server for biology (2024)
Timothy F. Huddy,Yang Hsia,Ryan D. Kibler,Jinwei Xu, Neville Bethel, Deepesh Nagarajan,Rachel Redler,Philip J. Y. Leung,Connor Weidle,Alexis Courbet,Erin C. Yang,Asim K. Bera,
Bartlomiej Porebski,Wanda Christ,Alba Corman,Martin Haraldsson,Myriam Barz,Louise Lidemalm,Maria Haggblad, Juliana Illmain,Shane Wright, Matilde Murga,Jan Schlegel,Erdinc Sezgin,
bioRxiv (Cold Spring Harbor Laboratory) (2024)
James Chen, Alice Fruhauf,Catherine Fan, Jackeline Ponce,Beatrix Ueberheide,Gira Bhabha,Damian C. Ekiert
Brianna Romer,Sophie M Travis,Brian P Mahon, Collin T McManus,Philip D Jeffrey,Nicolas Coudray, Rishwanth Raghu,Michael J Rale,Ellen D Zhong,Gira Bhabha,Sabine Petry
bioRxiv : the preprint server for biology (2023)
Juliana K Ilmain,Sofya S Perelman, Maria C Panepinto,Irnov Irnov,Nicolas Coudray, Nora Samhadaneh,Alejandro Pironti,Beatrix Ueberheide,Damian C Ekiert,Gira Bhabha,Victor J Torres
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