基本信息
浏览量:60
职业迁徙
个人简介
Efficacy of human induced pluripotent stem cell (hiPSC) lines to improve functional outcomes in cervical SCI.
We are investigating the efficacy of human iPSC lines differentiated into neuronal transplants to form relay/bridging grafts after acute SCI in the cervical spinal cord. Within these studies we are exploring the ability of these neurons, in conjunction with biomaterials, intensive rehabilitation, to induce long tract growth, synapse formation to the host spinal cord, and overall improve functional recovery. The long-term goals are to develop neuroprotective and regenerative translational protocols for human clinical treatments. It is hoped that patients will have improved motor, sensory and autonomic functions, as well as experiencing fewer secondary complications such as bladder and bowel dysfunction, autonomic dysreflexia, pain and spasticity; the goal is in improving the quality of life for patients with SCI.
We are investigating the efficacy of human iPSC lines differentiated into neuronal transplants to form relay/bridging grafts after acute SCI in the cervical spinal cord. Within these studies we are exploring the ability of these neurons, in conjunction with biomaterials, intensive rehabilitation, to induce long tract growth, synapse formation to the host spinal cord, and overall improve functional recovery. The long-term goals are to develop neuroprotective and regenerative translational protocols for human clinical treatments. It is hoped that patients will have improved motor, sensory and autonomic functions, as well as experiencing fewer secondary complications such as bladder and bowel dysfunction, autonomic dysreflexia, pain and spasticity; the goal is in improving the quality of life for patients with SCI.
研究兴趣
论文共 85 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
V. M. Doulames, L. M. Marquardt, M. E. Hefferon, N. J. Baugh, R. A. Suhar, K. R. Dubbin, J. M. Weimann, T. D. Palmer,G. W. Plant,S. C. Heilshorn
BIOMATERIALS (2024): 122400-122400
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn