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He was also responsible for the patient care unit at the University Hospital of Careggi (SOD Patologia Medica). Gianfranco was well-known internationally and he spent time as a visiting scientist at several prestigious institutions abroad during his career. Of particular note are his appointments first at the Department of Immunology at Harvard Medical School, Boston, USA, where he worked with Prof. R.
Geha, and then at the Basel Institute for Immunology in Basel, Switzerland, where he worked with Dr. A. Lanzavecchia. From 2005 until 2008 he made several short visits to The Biodesign Institute, Arizona State University, Phoenix-Tempe, USA, collaborating with Prof. R. Curtis and Prof. C. Arntzen.
His scientific interests and activities were in different areas of basic and clinical immunology, particularly in the pathophysiology of the immune response, the host immune response to pathogens, the
pathogenetic aspects of organ-specific autoimmune diseases, and the pathogenesis of allergy. Through his lifetime he contributed more than 200 internationally recognized publications and received distinguished national and international awards. Gianfranco and his co-workers made significant contributions to the definition of the phenotypic and functional features of T lymphocyte subsets known as Th1 and Th2. In an elegant paper published in the Journal of Experimental Medicine in1991, he demonstrated that Th1 differ from Th2 human T cell clones not only by their profiles of cytokine secretion, but also for cytolytic potential and mode of help for B cell Ig synthesis. He made many other notable contributions to the understanding of host immune responses to bacterial and parasite pathogens. In the last years his major research activities focused on important scientific issues related to developing countries and his work provided strong evidence for the potential use of plant-derived antigens in an oral vaccine for the prevention of plague.
Geha, and then at the Basel Institute for Immunology in Basel, Switzerland, where he worked with Dr. A. Lanzavecchia. From 2005 until 2008 he made several short visits to The Biodesign Institute, Arizona State University, Phoenix-Tempe, USA, collaborating with Prof. R. Curtis and Prof. C. Arntzen.
His scientific interests and activities were in different areas of basic and clinical immunology, particularly in the pathophysiology of the immune response, the host immune response to pathogens, the
pathogenetic aspects of organ-specific autoimmune diseases, and the pathogenesis of allergy. Through his lifetime he contributed more than 200 internationally recognized publications and received distinguished national and international awards. Gianfranco and his co-workers made significant contributions to the definition of the phenotypic and functional features of T lymphocyte subsets known as Th1 and Th2. In an elegant paper published in the Journal of Experimental Medicine in1991, he demonstrated that Th1 differ from Th2 human T cell clones not only by their profiles of cytokine secretion, but also for cytolytic potential and mode of help for B cell Ig synthesis. He made many other notable contributions to the understanding of host immune responses to bacterial and parasite pathogens. In the last years his major research activities focused on important scientific issues related to developing countries and his work provided strong evidence for the potential use of plant-derived antigens in an oral vaccine for the prevention of plague.
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NATO Science for Peace and Security Series A-Chemistry and Biologypp.357-+, (2010)
Cancer Immunology, Immunotherapyno. 11 (2009): 1819-1830
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