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The research focus of our laboratory is the investigation of neuroinflammatory mechanisms involved in the development of psychiatric disorders. In particular we are interested in the role played by the inflammatory circulating mediators cytokines, and more recently adipokines such as leptin, which are involved in regulating both acute and chronic sickness behaviour via direct action in the brain. The work on adipokines in particular has led us to explore the link between the energy status of an individual, their ability to mount an immune response to pathogens and their increased susceptibility to developing psychopathology. In parallel to this work we are exploring the impact of prenatal environmental insults such as bacterial or viral infection and maternal diet on the normal development of the fetal brain. This work is based on the rationale that dysregulation of the mother’s immune response, following the insult can result in neurodevelopmental defects. We believe that this is linked to disruption of normal neuronal network formation involving microglia in the fetal brain, which could lead to brain disorders such as schizophrenia, and autism spectrum disorders in the adult offspring.
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论文共 102 篇作者统计合作学者相似作者
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Chin W Hui, Abygaël St-Pierre, Hassan El Hajj, Yvan Remy,Sébastien S Hébert,Giamal N Luheshi,Lalit K Srivastava,Marie-Ève Tremblay
Kanchan Bisht, Kaushik P. Sharma,Cynthia Lecours,Maria Gabriela Sánchez, Hassan El Hajj,Giampaolo Milior,Adrian Olmos-Alonso,Diego Gomez-Nicola,Giamal N. Luheshi,Luc Vallières,Igor Branchi,Laura Maggi,
Brain, behavior, and immunity (2016): 88-98
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