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The research group on Structure and function of molecular motors of A/Prof. G. Gruber in the Division of Structural and Computational Biology, SBS, NTU, is recognized for their expertise in determining the relationships between the structure and function of the so-called A1AO ATP synthases, V1VO ATPases, F1FO ATP synthases and AAA-ATPases. These enzymes are proposed to be the smallest biological motor proteins (nano-motor proteins). In order to get inside into the structure of these multi-subunit membrane complexes techniques like single particle analysis of electron micrographs, solution X-ray scattering, X-ray crystallography and NMR-spectroscopy are used. The functional and dynamical processes inside these enzymes are studied by fluorescence spectroscopy (e.g. FRET, FCS, intrinsic fluorescence spectroscopy) and biochemical approaches.
Research Activities
The research group on Structure and function of molecular motors of A/Prof. G. Gruber in the Division of Structural and Computational Biology, SBS, NTU, is recognized for their expertise in determining the relationships between the structure and function of the so-called A1AO ATP synthases, V1VO ATPases, F1FO ATP synthases and AAA-ATPases. These enzymes are proposed to be the smallest biological motor proteins (nano-motor proteins). In order to get inside into the structure of these multi-subunit membrane complexes techniques like single particle analysis of electron micrographs, solution X-ray scattering, X-ray crystallography and NMR-spectroscopy are used. The functional and dynamical processes inside these enzymes are studied by fluorescence spectroscopy (e.g. FRET, FCS, intrinsic fluorescence spectroscopy) and biochemical approaches.
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The Journal of biological chemistryno. 2 (2024): 105618-105618
My Hanh Bui,Shu Hui Hiew, Teddy Salim, Wan Geok Saw,Richard D. Webster,Gerhard Grüber,Yuguang Mu,Ali Miserez
Communications Materialsno. 1 (2024): 1-15
ANTIMICROBIAL AGENTS AND CHEMOTHERAPYno. 6 (2023)
EXPERT OPINION ON DRUG DISCOVERYno. 8 (2023): 917-927
FEBS Lettersno. 15 (2023): 1977-1988
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Biochemical and Biophysical Research Communications (2023): 140-145
Syed Moiz Ahmed,Priya Ragunathan,Joon Shin,Sabrina Peter, Sabrina Kleissle,Martin Neuenschwander,Reinhold Schäfer, Jens Peter v. Kries,Gerhard Grüber,Peter Dröge
crossref(2023)
Priya Ragunathan, Pearly Shuyi Ng,Samsher Singh,Wee Han Poh,Dennis Litty,Nitin Pal Kalia, Simon Larsson,Amaravadhi Harikishore,Scott A. Rice,Philip W. Ingham, Volker Mueller,Garrett Moraski,
MICROBIOLOGY SPECTRUMno. 6 (2023): e0228223-e0228223
Wuan-Geok Saw, Khoa Cong Minh Le,Joon Shin,Jes Hui Min Kwek,Chui Fann Wong,Priya Ragunathan, Tuck Choy Fong, Volker Mueller,Gerhard Grueber
FASEB journal : official publication of the Federation of American Societies for Experimental Biologyno. 7 (2023): e23040-e23040
Expert opinion on drug discoverypp.1-11, (2023)
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