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Dr. Christ has a broad interest in muscle physiology, intercellular communication and the role of muscle in the function and dysfunction of visceral, vascular and voluntary tissues (i.e., skeletal muscle). His research interests include physiological genomics, that is, establishing a verifiable link between changes in gene expression and alterations in cell/organ/tissue function/dysfunction, and then using this information to improve the understanding, diagnosis and treatment of smooth muscle diseases/disorders. To this end, Dr. Christ has developed a multidisciplinary approach that utilizes various visceral and vascular smooth muscle tissues/organs to attempt to establish “cause and effect” relationships between molecular/genetic alterations and measurable changes in organ function, namely, contraction and relaxation of smooth muscle cells. Animal vascular and visceral tissues are studied both in vitro and in vivo. Molecular, biochemical, electrophysiological, pharmacological, immunochemical, and whole animal techniques (rat and mouse transgenics and knockouts) are all used to study the mechanistic basis for integrative tissue physiology, as well as tissue pathophysiology, dysfunction and therapeutic repair. Parallel in vitro studies are conducted on corresponding human tissues for target validation whenever possible.
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Walter B. Varhue,Aditya Rane, Ramon Castellanos-Sanchez,Shayn M. Peirce,George Christ,Nathan S. Swami
Organs-on-a-Chip (2022): 100017
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Sarah E Dyer,J David Remer, Kelsey E Hannifin, Aishwarya Hombal,Joseph C Wenke,Thomas J Walters,George J Christ
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