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Research
1. The discovery, early development and preclinical validation of protein therapeutics for the treatment of cancer, inborn errors of metabolism disorders and other diseases. Our lab has invented and played a key role in the early development of one FDA approved therapeutic protein and four proteins that are currently in clinical trials
2. Molecular level understanding of human antibody immunity. We have developed technologies for determining the identity (sequence), relative abundance and function of the ensemble of circulating antibodies that are elicited as a result of infection, vaccination or in disease states such as cancer and autoimmunity. The application of these technologies is providing important insights that inform vaccine design and aid in the discovery of very potent human therapeutic antibodies.
3. Engineering of the Fc domain of therapeutic antibodies to develop, “second generation” improved therapeutics and to expand our understanding of how antibodies interact with other components of the immune system to help eradicate disease-causing cells.
1. The discovery, early development and preclinical validation of protein therapeutics for the treatment of cancer, inborn errors of metabolism disorders and other diseases. Our lab has invented and played a key role in the early development of one FDA approved therapeutic protein and four proteins that are currently in clinical trials
2. Molecular level understanding of human antibody immunity. We have developed technologies for determining the identity (sequence), relative abundance and function of the ensemble of circulating antibodies that are elicited as a result of infection, vaccination or in disease states such as cancer and autoimmunity. The application of these technologies is providing important insights that inform vaccine design and aid in the discovery of very potent human therapeutic antibodies.
3. Engineering of the Fc domain of therapeutic antibodies to develop, “second generation” improved therapeutics and to expand our understanding of how antibodies interact with other components of the immune system to help eradicate disease-causing cells.
研究兴趣
论文共 560 篇作者统计合作学者相似作者
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Sunil Singhal,Abhishek S. Rao,Jason Stadanlick, Kyle Bruns,Neil T. Sullivan, Andres Bermudez, Adam Honig-Frand, Ryan Krouse, Sachinthani Arambepola,Emily Guo, Edmund K. Moon,George Georgiou,
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Sunil Singhal,Abhishek S. Rao,Jason Stadanlick, Kyle Bruns,Neil T. Sullivan, Andres Bermudez, Adam Honig-Frand, Ryan Krouse, Sachinthani Arambepola,Emily Guo, Edmund K. Moon,George Georgiou,
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Alessandra Araujo,Joseph Dekker, Kendra Garrison, Zhe Su,Catherine Oana Rhee,Zicheng Hu,Bum-Kyu Lee, Daniel Hurtado, Jiwon Li,Vishwanath Iyer,Lauren I. R. Ehrlich,George Georgiou,
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