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Our laboratory is performing studies of the "Incretin Mimetics", a newly recognized class of blood glucose-lowering agents that stimulate pancreatic insulin secretion, and which are likely to be the next line of defense for the treatment of type 2 diabetes mellitus. Incretin mimetics mimic the action of GLP-1 (glucagon-like peptide-1), a naturally-occurring incretin hormone secreted by L-cells of the intestine, and which when administered to type 2 diabetic subjects, lowers concentrations of blood glucose.
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Amber Liles, Nancy Cham, Morgan L. Opp,Ian C. Tinsley,Oleg G. Chepurny,George G. Holz,Robert P. Doyle
PEPTIDES (2024): 171134-171134
Vigga Laursen,Aaraby Nielsen, Johan Dam, Simone Abild,Christina Baun, Oleg Chepurny, Birgitte Olsen,George Holz,Berthold A. Nock, Theodosia Maina-Nock,Helge Thisgaard
Nuclear Medicine and Biology (2023): 108797-108797
biorxiv(2023)
Giorgio Basile,Amedeo Vetere,Jiang Hu,Oluwaseun Ijaduola,Yi Zhang,Ka-Cheuk Liu,Amira M Eltony,Dario F De Jesus, Kazuki Fukuda, Grace Doherty,Colin A Leech,Oleg G Chepurny,
Cell metabolismno. 7 (2023): 1242-1260.e9
Over Cabrera,James Ficorilli, Janice Shaw, Felipe Echeverri,Frank Schwede,Oleg G Chepurny,Colin A Leech,George G Holz
Qinghe Meng, Oleg G. Chepurny, Colin A. Leech, Napat Pruekprasert, Megan E. Molnar, J. Jason Collier, Robert N. Cooney, George G. Holz
crossref(2022)
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