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My research interests span solid-state chemistry to enzyme structure and function to origin of life studies. Much of this research is underpinned by use of X-ray diffraction techniques as the ultimate "microscope" into the structure of matter. I am increasingly interested in the role that entropy, the "dynamics of thermodynamics", plays in protein structure and function. NMR techniques give insight into this fourth dimension of time.
I am also interested in the evolution of protein structure and the role that the quaternary structure of proteins plays in controlling protein dynamics to optimise substrate specificity and activity, a role quite different to the cooperative functions generally associated with multi-subunit protein structures.
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Maksim V Kvach, Stefan Harjes, Harikrishnan M Kurup,Geoffrey B Jameson,Elena Harjes,Vyacheslav V Filichev
Beilstein journal of organic chemistryno. 1 (2024): 1088-1098
Stefan Harjes,Harikrishnan M. Kurup, Amanda E. Rieffer,Maitsetseg Bayarjargal, Jana Filitcheva,Yongdong Su,Tracy K. Hale,Vyacheslav V. Filichev,Elena Harjes,Reuben S. Harris,Geoffrey B. Jameson
biorxiv(2023)
Nature Chemistryno. 10 (2023): 1358-1364
Geoffrey Jameson,Stefan Harjes,Harikrishnan Kurup,Amanda Rieffer, Maitsetseg Bayarjargal, Jana Filichetva,Yongdong Su,Tracy Hale,Vyacheslav Filichev,Elena Harjes,Reuben Harris
crossref(2023)
Molecules (Basel, Switzerland)no. 8 (2023): 3573-3573
Biochemistryno. 17 (2023): 2669-2676
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