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职业迁徙
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Research Interests
Host Immune and Inflammatory Responses to Infections, Tissue Injuries, Cancers and Metabolic Challenges: Our research at UCLA is aimed towards understanding innate and adaptive immune responses in host defense against infections and cancers, as well as their associations with inflammatory and metabolic diseases. Upon recognizing pathogenic infections and other environmental challenges, host cellular receptors can trigger a series of signal transduction and gene expression networks (gene programs) to initiate innate immune responses. These responses can, for example, control the replication and spread of bacteria and viruses by activating phagocytes and inducing the release of antimicrobial proteins and/or type I interferons. In addition, innate immune responses are essential in the development of humoral and cellular adaptive immunity by enhancing antigen presentation and upregulating co-stimulatory molecules. A defect at any step of this well-coordinated process can increase host susceptibility to infection. On the other hand, overactive immune responses can also lead to multiple inflammatory disorders and metabolic syndromes. We hope to understand both the similarities and differences in host immune responses to infections by different types of pathogens. We also hope to better appreciate how we balance immune and inflammatory responses, and how these responses influence other homeostatic and metabolic processes. Our goal is to develop novel strategies to enhance our immunity against infections and tumor challenges, while preventing or inhibiting inflammatory and metabolic diseases.
Host Immune and Inflammatory Responses to Infections, Tissue Injuries, Cancers and Metabolic Challenges: Our research at UCLA is aimed towards understanding innate and adaptive immune responses in host defense against infections and cancers, as well as their associations with inflammatory and metabolic diseases. Upon recognizing pathogenic infections and other environmental challenges, host cellular receptors can trigger a series of signal transduction and gene expression networks (gene programs) to initiate innate immune responses. These responses can, for example, control the replication and spread of bacteria and viruses by activating phagocytes and inducing the release of antimicrobial proteins and/or type I interferons. In addition, innate immune responses are essential in the development of humoral and cellular adaptive immunity by enhancing antigen presentation and upregulating co-stimulatory molecules. A defect at any step of this well-coordinated process can increase host susceptibility to infection. On the other hand, overactive immune responses can also lead to multiple inflammatory disorders and metabolic syndromes. We hope to understand both the similarities and differences in host immune responses to infections by different types of pathogens. We also hope to better appreciate how we balance immune and inflammatory responses, and how these responses influence other homeostatic and metabolic processes. Our goal is to develop novel strategies to enhance our immunity against infections and tumor challenges, while preventing or inhibiting inflammatory and metabolic diseases.
研究兴趣
论文共 260 篇作者统计合作学者相似作者
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Huimin Fan,Wancheng Liu, Yanqiong Zeng, Ying Zhou,Meiling Gao,Liping Yang,Hao Liu,Yueyue Shi,Lili Li, Jiayuan Ma,Jiayin Ruan,Ruyun Cao,
Dakai Liu,Yexiao Cheng,Hangyu Zhou,Lulan Wang,Roberto Hurtado Fiel, Yehudah Gruenstein, Jean Jingzi Luo,Vishnu Singh,Eric Konadu,Keither James, Calvin Lui, Pengcheng Gao,
Nida Ozarslan,Joshua F. Robinson,Sirirak Buarpung,M. Yvonne Kim, Megan R. Ansbro,Jason Akram,Dennis J. Montoya,Moses R. Kamya, Abel Kakuru,Grant Dorsey,Philip J. Rosenthal,Genhong Cheng,
biorxiv(2023)
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Manuel F. Lopez-Aranda,Gayle M. Boxx,Miranda Phan, Karen Bach,Rochelle Mandanas, Isaiah Herrera,Sunrae Taloma,Chirag Thadani,Odilia Lu, Raymond Bui,Shuhan Liu,Nan Li,
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCEno. 3 (2023): 451-459
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