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Vascular causes of cognitive impairment and dementia is my main area of interest. At the UMC Brain Center of the University Medical Centre Utrecht, the Netherlands, I have established a multidisciplinary research program on vascular cognitive impairment (VCI) and small vessel diseases (SVDs). Our particular focus is on novel imaging markers of VCI and SVDs, that can improve diagnosis and support development of treatment. We implement the latest insights in our VCI clinic.
Using the unique properties of high field 7T-MRI we have been able – for the first time -to detect cerebral microinfarcts in vivo and we have subsequently translated the technique to 3T-MRI, and published standards on microinfarct detection in The Lancet Neurology. Currently we 1) explore small vessel disease in VCI at the level of the small vessels themselves, through novel measures of small vessel structure and function at 7T MRI, thus getting to the core disease processes and 2) improve understanding of the functional impact of vascular lesions through large multicenter lesion symptom mapping studies (through the META VCI MAP consortium; first results in The Lancet Neurology, 2021) and white matter network studies using diffusion MRI.
Another topic of interest is cognitive impairment in relation to diabetes. We have characterized trajectories and stages of cognitive dysfunction and established underlying structural brain changes with MRI. I served as PI of two large multicentre RCTs on prevention of cognitive decline in patients with in type 2 diabetes. I was also involved in clinical guidelines. From 2016, I serve as a consultant on the brain MRI and cognition outcomes of the Diabetes Control & Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications Study (EDIC) Cohort”, and several other NIH funded programs.
I work with international collaborators in Munich, Edinburgh, Seoul, Hong Kong, and Singapore and participate in the multinational EU-funded research programs SVDs@target and RECOGNISED. In 2016 I was appointed Fellow of the Royal College of Physicians Edinburgh and in 2015 I received the senior investigator award of the European Stroke Organisation (ESO) in recognition of my work.
研究兴趣
论文共 606 篇作者统计合作学者相似作者
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J. Matthijs Biesbroek, Mirthe Coenen,Charles DeCarli,Evan M. Fletcher,Pauline M. Maillard,Frederik Barkhof,Josephine Barnes,Thomas Benke, Christopher P. L. H. Chen,Peter Dal-Bianco,Anna Dewenter,Marco Duering,
ALZHEIMERS & DEMENTIA (2024)
ALZHEIMERS & DEMENTIAno. 3 (2024): 2209-2222
Marvin Petersen,Mirthe Coenen,Charles DeCarli,Alberto De Luca, Ewoud van der Lelij, Alzheimer’s Disease Neuroimaging Initiative,Frederik Barkhof,Thomas Benke, Christopher P L H Chen, Peter Dal-Bianco,Anna Dewenter,Marco Duering,
medRxiv : the preprint server for health sciences (2024)
INTERNATIONAL JOURNAL OF STROKEno. 1 (2024): 7-15
Charlotte M. Nijskens, Elias G. Thomas,Hanneke F. M. Rhodius-Meester, Mat J. A. P. Daemen,Geert Jan Biessels,M. Louis Handoko,Majon Muller
CLINICAL CARDIOLOGYno. 1 (2024): e24200-e24200
Cerebral Circulation - Cognition and Behavior (2024): 100219
Mirthe Coenen, Floor A S de Kort, Nick A Weaver,Hugo J Kuijf,Hugo Paul Aben, Hee-Joon Bae,Régis Bordet, Christopher Lh Chen, Anna Dewenter, Thomas Doeven,Thibaut Dondaine, Marco Duering,
International journal of stroke : official journal of the International Stroke Societypp.17474930241252530-17474930241252530, (2024)
Roberto Duarte Coello,Maria del C. Valdes Hernandez,Jaco J. M. Zwanenburg, Moniek van der Velden,Hugo J. Kuijf,Alberto De Luca, Jose Bernal Moyano,Lucia Ballerini,Francesca M. Chappell,Rosalind Brown,Geert Jan Biessels,Joanna M. Wardlaw
JOURNAL OF NEUROSCIENCE METHODS (2024): 110039-110039
Mateus Rozalem Aranha,Victor Montal,Hilde van den Brink, Jordi Pegueroles,Maria Carmona-Iragui,Laura Videla, Lucia Maure Blesa,Bessy Benejam, Javier Arranz, Sílvia Valldeneu, Isabel Barroeta, Susana Fernández,
Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
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